Neuronal loss due to prolonged controlled-current stimulation with chronically implanted microelectrodes in the cat cerebral cortex.
Neuronal loss due to prolonged controlled-current stimulation with chronically implanted microelectrodes in the cat cerebral cortex.
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DOI：
10.1088/1741-2560/7/3/036005
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发表时间：
2010-06
影响因子：
4
通讯作者：
Troyk PR
中科院分区：
文献类型：
--
作者：
McCreery D;Pikov V;Troyk PR
将激活的铱微电极植入7只成年家猫的感觉运动皮层450 ~ 1282天，然后以50 Hz脉冲240小时（每天8小时，30天）。以2 nC/相和100 μC/cm2的几何电荷密度连续刺激，微电极尖端周围组织的神经元密度无明显变化。然而，在4 nC/ph下连续（100%占空比）、几何电荷密度为200 μC/cm2的脉冲会导致电极尖端至少150 μm半径范围内皮质神经元的损失。同样的刺激方案，但占空比为50%（刺激1秒，然后无刺激1秒，重复8小时）会在距离电极尖端中心约60 μm的较小半径内产生神经元损失。然而，未脉冲电极周围的神经元也有明显的损失，这可能是由于电极插入并长期驻留在组织中的机械损伤造成的，这是导致以50%占空比脉冲电极150 μm范围内的大部分神经元损失的原因。
Activated Iridium microelectrodes were implanted for 450 to 1282 days in the sensorimotor cortex of 7 adult domestics cats and then pulsed for 240 hours (8 hours per day for 30 days) at 50 Hz. Continuous stimulation at 2 nC/phase and with a geometric charge density of 100 μC/cm2 produced no detectable change in neuronal density in the tissue surrounding the microelectrode tips. However, pulsing with a continuous (100% duty cycle) at 4 nC/ph and with a geometric charge density of 200 μC/cm2 induced loss of cortical neurons over a radius of at least 150 μm from the electrode tips. The same stimulus regimen, but with a duty cycle of 50% (1 sec of stimulation, then 1 second without stimulation repeated for 8 hours) produced neuronal loss within a smaller radius, approximately 60 μm from the center of the electrode tips. However, there also was significant loss of neurons surrounding the unpulsed electrodes, presumably as a result of mechanical injury due to their insertion into and long-term residence in the tissue, and this was responsible for most of the neuronal loss within 150 μm of the electrodes pulsed with the 50% duty cycle.
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DOI：
10.1109/tnsre.2006.870495
发表时间：
2006-03-01
影响因子：
4.9
作者：
Liu, XD;McCreery, DB;Agnew, WF
通讯作者：
Agnew, WF
影响因子：
2.8
作者：
MCCREERY, DB;YUEN, TGH;BULLARA, LA
通讯作者：
BULLARA, LA
影响因子：
14.5
作者：
Schmidt, EM;Bak, MJ;Vallabhanath, P
通讯作者：
Vallabhanath, P
DOI：
10.1109/86.788468
发表时间：
1999-09-01
期刊：
IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Liu, X;McCreery, D B;Agnew, W F
通讯作者：
Agnew, W F
影响因子：
3.8
作者：
McCreery, DB;Agnew, WF;Bullara, LA
通讯作者：
Bullara, LA