Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.
Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.
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DOI：
10.1093/infdis/jis676
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发表时间：
2013-01-15
期刊：
影响因子：
--
通讯作者：
Dunne DW
中科院分区：
文献类型：
--
作者：
Pinot de Moira A;Sousa-Figueiredo JC;Jones FM;Fitzsimmons CM;Betson M;Kabatereine NB;Stothard JR;Dunne DW
慢性血吸虫感染和过敏期间特异性免疫球蛋白 E (IgE) 反应上调。这些反应在血吸虫病期间受到严格调节。我们之前已经表明，IgE 调节取决于接触单个寄生虫过敏原样蛋白的程度和时间。在这里，我们比较了来自曼氏血吸虫传播程度不同的 2 个村庄的学龄前儿童对差异表达的过敏原样蛋白 SmTAL1 和 SmTAL2 的 IgE 和免疫球蛋白 G4 (IgG4) 反应的发展。我们发现所有儿童都缺乏 SmTAL1 反应性，但有证据表明两个村庄都存在 IgG4 依赖性 IgE-SmTAL2 脱敏，并且在传播水平较高的村庄的儿童中发生得更早。研究结果提供了对过敏型免疫反应的发展和调节的见解。
Specific immunoglobulin E (IgE) responses are upregulated during chronic schistosome infection and during allergy. These responses are tightly regulated during schistosomiasis. We have previously shown that IgE regulation depends on the extent and length of exposure to individual parasite allergen-like proteins. Here we compare the development of IgE and immunoglobulin G4 (IgG4) responses to the differentially expressed allergen-like proteins SmTAL1 and SmTAL2 among preschool-aged children from 2 villages with different levels of Schistosoma mansoni transmission. We found a lack of SmTAL1 responsiveness among all children, but evidence for IgG4-dependent IgE-SmTAL2 desensitization in both villages, occurring earlier among children from the village where the level of transmission was greater. Findings provide insights into the development and regulation of allergic-type immune responses.
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DOI：
10.4269/ajtmh.1968.17.38
发表时间：
1968-01-01
影响因子：
3.3
作者：
CHEEVER, AW
通讯作者：
CHEEVER, AW
影响因子：
2.4
作者：
Stothard, J. Russell;Sousa-Figueiredo, Jose C.;Betson, Martha;Green, Helen K.;Seto, Edmund Y. W.;Garba, Amadou;Sacko, Moussa;Mutapi, Francisca;Nery, Susana Vaz;Amin, Mutamad A.;Mutumba-Nakalembe, Margaret;Navaratnam, Annalan;Fenwick, Alan;Kabatereine, Narcis B.;Gabrielli, Albis F.;Montresor, Antonio
通讯作者：
Montresor, Antonio
影响因子：
14.2
作者：
Wachholz, PA;Soni, NK;Durham, SR
通讯作者：
Durham, SR
影响因子：
3.8
作者：
Fitzsimmons CM;Jones FM;Stearn A;Chalmers IW;Hoffmann KF;Wawrzyniak J;Wilson S;Kabatereine NB;Dunne DW
通讯作者：
Dunne DW
DOI：
10.4269/ajtmh.2010.10-0307
发表时间：
2010-11-01
影响因子：
3.3
作者：
Betson, Martha;Figueiredo, Jose Carlos Sousa;Stothard, J. Russell
通讯作者：
Stothard, J. Russell