Which cue to 'want'? Opioid stimulation of central amygdala makes goal-trackers show stronger goal-tracking, just as sign-trackers show stronger sign-tracking.
Which cue to 'want'? Opioid stimulation of central amygdala makes goal-trackers show stronger goal-tracking, just as sign-trackers show stronger sign-tracking.
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DOI：
10.1016/j.bbr.2012.02.032
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Berridge, Kent C.
中科院分区：
文献类型：
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作者：
DiFeliceantonio, Alexandra G.;Berridge, Kent C.
巴甫洛夫式的暗示与奖励搭配在一起，可以获得激励的显著效果。吸毒者发现毒品线索具有激励吸引力，而暴饮者则被食物线索所吸引。但是，线索重遇引起的激励显著程度仍因时间和大脑状态而异。在动物模型中，线索在“自动塑造”范式中变得吸引人和“想要”，不同的个体会出现不同的激励显著目标。一些人(符号跟踪者)认为预测性的离散线索很有吸引力，而另一些人则认为奖励是连续的，目标线索更有吸引力(奖励到达的位置：目标跟踪器)。在这里，我们评估了中央杏仁核单位阿片受体刺激是否在预测性线索存在的时刻(表现在对目标线索的接近和消耗行为中)增强了目标线索对目标追踪者的相位性激励突显，就像它提高了预测线索目标对手势跟踪者的吸引力一样。使用详细的视频分析，我们测量了针对手势跟踪器和目标跟踪器的首选目标的接近、轻咬、嗅探和咬人。我们报告说，杏仁中央核的DAMGO微量注射使目标追踪器，如手势追踪器，在食欲和嗅觉中显示出阶段性增加-每当预测线索出现时，选择性地表达目标线索。这表明目标跟踪者和符号跟踪者的激励显著都有所增强，但归因于不同的方向：各自归因于自己的目标线索。对于这两种表型，杏仁核阿片样刺激使个体的优势线索在CS触发的阶段变成更强的动机磁铁，CS预测奖励UCS。
Pavlovian cues that have been paired with reward can gain incentive salience. Drug addicts find drug cues motivationally attractive and binge eaters are attracted by food cues. But the level of incentive salience elicited by a cue re-encounter still varies across time and brain states. In an animal model, cues become attractive and ‘wanted’ in an ‘autoshaping’ paradigm, where different targets of incentive salience emerge for different individuals. Some individuals (sign-trackers) find a predictive discrete cue attractive while others find a reward contiguous and goal cue more attractive (location where reward arrives: goal-trackers). Here we assessed whether central amygdala mu opioid receptor stimulation enhances the phasic incentive salience of the goal-cue for goal-trackers during moments of predictive cue presence (expressed in both approach and consummatory behaviors to goal cue), just as it enhances the attractiveness of the predictive cue target for sign-trackers. Using detailed video analysis we measured the approaches, nibbles, sniffs, and bites directed at their preferred target for both sign-trackers and goal-trackers. We report that DAMGO microinjections in central amygdala made goal-trackers, like sign-trackers, show phasic increases in appetitive nibbles and sniffs directed at the goal-cue expressed selectively whenever the predictive cue was present. This indicates enhancement of incentive salience attributed by both goal trackers and sign-trackers, but attributed in different directions: each to their own target cue. For both phenotypes, amygdala opioid stimulation makes the individual’s prepotent cue into a stronger motivational magnet at phasic moments triggered by a CS that predicts the reward UCS.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
2.7
作者：
Holden, John Michael;Peoples, Laura L.
通讯作者：
Peoples, Laura L.
影响因子：
2.7
作者：
BOAKES, RA;POLI, M;GOODALL, G
通讯作者：
GOODALL, G
影响因子：
2.7
作者：
Flagel, Shelly B.;Watson, Stanley J.;Robinson, Terry E.
通讯作者：
Robinson, Terry E.
DOI：
10.1037/0097-7403.34.2.202
发表时间：
2008-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
Delamater, Andrew R.;Holland, Peter C.
通讯作者：
Holland, Peter C.