Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma.
Biocompatible carbon-doped MoSe(2) nanoparticles as a highly efficient targeted agent for human renal cell carcinoma.
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生物相容性碳掺杂 MoSe2 纳米粒子作为人类肾细胞癌的高效靶向药物
作者：
MoSe 2是一种典型的过渡金属二硫族化合物材料，利用其近红外强吸收特性进行激光光热治癌已成为研究的热点。然而，MoSe 2对肾细胞癌（RCC）的抗肿瘤作用及其可能机制尚不清楚。肾细胞癌是泌尿系统最致命的恶性肿瘤之一，具有较高的转移率。结果表明，碳掺杂的MoSe 2颗粒对786-O和ACHN细胞具有明显的增殖抑制作用。同时，碳掺杂的MoSe 2纳米颗粒对体外培养的KH-2细胞活力影响不大。机理分析表明，碳掺杂的MoSe 2颗粒在水溶液中具有氢键效应，颗粒聚集效应使KH-2细胞具有较高的存活率。具有最小毒性的碳掺杂的MoSe 2纳米颗粒可能是针对RCC的潜在治疗候选物。HK-2细胞具有弱的细胞摄取效率，导致碳掺杂的MoSe 2纳米颗粒的高存活率。
MoSe2 is a typical transition-metal dichalcogenide material, and many researches have been focused on using its property of near infrared strong absorption for laser mediated photothermal cancer treatment. However, the anti-canter effect of MoSe2 and its possible mechanism in renal cell carcinoma (RCC) is still unclear. RCC has high incidence of metastasis, which is known as one of the most lethal malignancies in the urological system. This study revealed that the carbon-doped MoSe2 particles can obviously inhibit proliferation for 786-O and ACHN cells. Meanwhile, the carbon-doped MoSe2 nanoparticles have little impact on the viability of KH-2 cells in vitro. The mechanism analysis revealed that the carbon-doped MoSe2 particles have hydrogen bond effect in aqueous solution, and the particle aggregation effect caused the KH-2 cells to have high viability. The carbon-doped MoSe2 nanoparticles with minimal toxicity may be a potential therapeutic candidate against RCC. HK-2 cells have weak cellular uptake efficiency leading to high viability with carbon-doped MoSe2 nanoparticles.
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影响因子：
17.1
作者：
Liu, Teng;Shi, Sixiang;Liang, Chao;Shen, Sida;Cheng, Liang;Wang, Chao;Song, Xuejiao;Goel, Shreya;Barnhart, Todd E.;Cai, Weibo;Liu, Zhuang
通讯作者：
Liu, Zhuang
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影响因子：
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DOI：
10.1016/j.msec.2017.03.195
发表时间：
2017-09-01
影响因子：
7.9
作者：
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通讯作者：
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影响因子：
11.9
作者：
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影响因子：
3.3
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