Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus.
Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus.
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DOI：
10.1371/journal.pone.0028962
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Shi GP
中科院分区：
文献类型：
--
作者：
Wang Z;Zhang H;Shen XH;Jin KL;Ye GF;Qian L;Li B;Zhang YH;Shi GP
最近的研究表明，肥大细胞活化和炎症在肥胖和糖尿病中很重要。肥大细胞蛋白酶和肥大细胞激活剂免疫球蛋白E（IgE）的血浆水平可能作为与糖尿病前期和糖尿病风险相关的新型炎症标志物。根据美国糖尿病协会2003年标准，将340名年龄在55至75岁之间的受试者分为正常葡萄糖耐量、糖尿病前期和糖尿病。Kruskal-Wallis检验显示，不同糖耐量状态组间血浆IgE水平存在显著差异（P=0.008）。 直线回归分析显示，血浆糜酶（P = 0.030）或IgE（P = 0.022）水平与糖尿病有显著相关性。 有序逻辑回归分析显示，IgE是糖尿病前期和糖尿病的重要危险因素（比值比[OR]：1.674，P = 0.034）。 在调整了常见的糖尿病危险因素，包括年龄、性别、高血压、体重指数、胆固醇、稳态模型评估（HOMA）指数、高敏C反应蛋白（hs-CRP）、肥大细胞糜酶和类胰蛋白酶后，IgE仍然是一个显著的危险因素（OR：1.866，P = 0.015）。 两变量有序Logistic回归分析显示，在调整糖尿病常见危险因素之前（OR：2.204，P = 0.044; OR：2.479，P = 0.033）和之后（OR：2.251，P= 0.040; OR：2.594，P = 0.026），hs-CRP与IgE或IgE与糜酶之间的交互作用进一步增加了糖尿病前期和糖尿病的风险。 IgE和糜酶均与糖尿病状态相关。虽然IgE和hs-CRP是糖尿病前期和糖尿病的个体危险因素，但IgE与hs-CRP或糜酶的相互作用进一步增加了糖尿病前期和糖尿病的风险。
Recent studies have suggested that mast-cell activation and inflammation are important in obesity and diabetes. Plasma levels of mast cell proteases and the mast cell activator immunoglobulin E (IgE) may serve as novel inflammatory markers that associate with the risk of pre-diabetes and diabetes mellitus. A total of 340 subjects 55 to 75 years of age were grouped according to the American Diabetes Association 2003 criteria of normal glucose tolerance, pre-diabetes, and diabetes mellitus. The Kruskal-Wallis test demonstrated significant differences in plasma IgE levels (P = 0.008) among groups with different glucose tolerance status. Linear regression analysis revealed significant correlations between plasma levels of chymase (P = 0.030) or IgE (P = 0.022) and diabetes mellitus. Ordinal logistic regression analysis showed that IgE was a significant risk factor of pre-diabetes and diabetes mellitus (odds ratio [OR]: 1.674, P = 0.034). After adjustment for common diabetes risk factors, including age, sex, hypertension, body-mass index, cholesterol, homeostatic model assessment (HOMA) index, high-sensitivity C-reactive protein (hs-CRP), and mast cell chymase and tryptase, IgE remained a significant risk factor (OR: 1.866, P = 0.015). Two-variable ordinal logistic analysis indicated that interactions between hs-CRP and IgE, or between IgE and chymase, increased further the risks of developing pre-diabetes and diabetes mellitus before (OR: 2.204, P = 0.044; OR: 2.479, P = 0.033) and after (OR: 2.251, P = 0.040; OR: 2.594, P = 0.026) adjustment for common diabetes risk factors. Both IgE and chymase associate with diabetes status. While IgE and hs-CRP are individual risk factors of pre-diabetes and diabetes mellitus, interactions of IgE with hs-CRP or with chymase further increased the risk of pre-diabetes and diabetes mellitus.
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影响因子：
2.8
作者：
Haffner, SM
通讯作者：
Haffner, SM
DOI：
10.1536/jhj.44.593
发表时间：
2003-09-01
期刊：
JAPANESE HEART JOURNAL
影响因子：
--
作者：
Erdogan, O;Altun, A;Ozbay, G
通讯作者：
Ozbay, G
影响因子：
8.2
作者：
Sabanayagam, C.;Shankar, A.;Wong, T. Y.
通讯作者：
Wong, T. Y.
影响因子：
7.7
作者：
Barzilay, JI;Abraham, L;Tracy, RP
通讯作者：
Tracy, RP
影响因子：
5.1
作者：
Haffner, SM
通讯作者：
Haffner, SM