The sum of many parts: potential mechanisms for improvement in glucose homeostasis after bariatric surgery.
The sum of many parts: potential mechanisms for improvement in glucose homeostasis after bariatric surgery.
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DOI：
10.1007/s11892-014-0481-5
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发表时间：
2014
影响因子：
4.2
通讯作者：
Korner, Judith
中科院分区：
文献类型：
--
作者：
Nguyen, Kim T.;Korner, Judith
关键词：
减肥手术已成为2型糖尿病（DM）最持久有效的治疗方法。然而，改善葡萄糖稳态的机制尚未完全阐明。在这篇综述中，我们讨论了各种类型的手术干预和众多的因素，可能介导的影响，如改变输送的营养素远端回肠，十二指肠排斥，肠道激素的变化，胆汁酸重吸收，和氨基酸代谢。越来越多的证据表明，这些变化中的一些似乎是独立的体重减轻问题的基本原理，使用体重指数作为手术的主要指征在糖尿病患者。了解改善血糖控制的复杂机制和相互作用可能会导致新的治疗目标，也将允许更大的个性化治疗和优化手术结果。
Bariatric surgery has emerged as the most durably effective treatment of type 2 diabetes (DM). However, the mechanisms governing improvement in glucose homeostasis have yet to be fully elucidated. In this review we discuss the various types of surgical interventions and the multitude of factors that potentially mediate the effects on glycemia, such as altered delivery of nutrients to the distal ileum, duodenal exclusion, gut hormone changes, bile acid reabsorption, and amino acid metabolism. Accumulating evidence that some of these changes seem to be independent of weight loss questions the rationale of using body mass index as the major indication for surgery in diabetic patients. Understanding the complex mechanisms and interactions underlying improved glycemic control could lead to novel therapeutic targets and would also allow for greater individualization of therapy and optimization of surgical outcomes.
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影响因子：
24.5
作者：
Depoortere, Inge
通讯作者：
Depoortere, Inge
影响因子：
2.9
作者：
Arterburn DE;Bogart A;Sherwood NE;Sidney S;Coleman KJ;Haneuse S;O'Connor PJ;Theis MK;Campos GM;McCulloch D;Selby J
通讯作者：
Selby J
影响因子：
6.9
作者：
Aguirre, Vincent;Stylopoulos, Nicholas;Grinbaum, Ronit;Kaplan, Lee M.
通讯作者：
Kaplan, Lee M.
影响因子：
3.1
作者：
DiGiorgi, Mary;Rosen, Daniel J.;Bessler, Marc
通讯作者：
Bessler, Marc
影响因子：
5.8
作者：
Falken, Y.;Hellstrom, P. M.;Naslund, E.
通讯作者：
Naslund, E.