Tenascin-C in Osteoarthritis and Rheumatoid Arthritis.
Tenascin-C in Osteoarthritis and Rheumatoid Arthritis.
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DOI：
10.3389/fimmu.2020.577015
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发表时间：
2020
影响因子：
7.3
通讯作者：
Sudo A
中科院分区：
文献类型：
--
作者：
Hasegawa M;Yoshida T;Sudo A
腱糖蛋白-C（TNC）是细胞外基质中的一种大型多模块糖蛋白，由四个不同的结构域组成。新出现的证据表明，TNC可能参与骨关节炎（OA）和类风湿关节炎（RA）的发病机制。在这篇综述中，我们总结了目前对TNC在骨关节炎和类风湿关节炎中在软骨和滑膜生物学方面所起作用的理解。TNC的表达与关节软骨的发育相关；在软骨细胞成熟过程中其表达降低，并且在成年关节软骨中几乎完全消失。在骨关节炎和类风湿关节炎中，病变的软骨、滑膜和滑液中TNC的表达增加。此外，在类风湿关节炎患者的血液中检测到循环TNC水平升高。因此，TNC可作为骨关节炎和类风湿关节炎的一种新型生化标志物，尽管它作为这些关节疾病的生化标志物没有特异性。在老年关节的创伤后骨关节炎模型中，TNC缺乏被证明会加剧软骨退变。用TNC结构域进行治疗会产生不同的、结构域特异性的效应，这些效应也是剂量依赖性的。例如，一些包括纤维蛋白原样球形结构域的TNC片段可能通过与Toll样受体 - 4结合而作为滑膜炎和软骨基质降解的内源性诱导物起作用，而全长TNC促进软骨修复并防止骨关节炎的发展且不会加剧滑膜炎。TNC肽TNIIIA2也能防止软骨退变且不会引起滑膜炎症。TNC对软骨和滑膜影响的临床意义尚不清楚，理解TNC的临床意义并非易事。
Tenascin-C (TNC) is a large multimodular glycoprotein of the extracellular matrix that consists of four distinct domains. Emerging evidence suggests that TNC may be involved in the pathogenesis of osteoarthritis (OA) and rheumatoid arthritis (RA). In this review, we summarize the current understanding of the role of TNC in cartilage and in synovial biology, across both OA and RA. TNC is expressed in association with the development of articular cartilage; the expression decreases during maturation of chondrocytes and disappears almost completely in adult articular cartilage. TNC expression is increased in diseased cartilage, synovium, and synovial fluid in OA and RA. In addition, elevated circulating TNC levels have been detected in the blood of RA patients. Thus, TNC could be used as a novel biochemical marker for OA and RA, although it has no specificity as a biochemical marker for these joint disorders. In a post-traumatic OA model of aged joints, TNC deficiency was shown to enhance cartilage degeneration. Treatment with TNC domains results in different, domain-specific effects, which are also dose-dependent. For instance, some TNC fragments including the fibrinogen-like globe domain might function as endogenous inducers of synovitis and cartilage matrix degradation through binding with toll-like receptor-4, while full-length TNC promotes cartilage repair and prevents the development of OA without exacerbating synovitis. The TNC peptide TNIIIA2 also prevents cartilage degeneration without causing synovial inflammation. The clinical significance of TNC effects on cartilage and synovium is unclear and understanding the clinical significance of TNC is not straightforward.
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影响因子：
7.8
作者：
CHIQUET, M;FAMBROUGH, DM
通讯作者：
FAMBROUGH, DM
影响因子：
2.6
作者：
Goldberg A;Mitchell K;Soans J;Kim L;Zaidi R
通讯作者：
Zaidi R
影响因子：
7
作者：
Chockalingam, P. S.;Glasson, S. S.;Lohmander, L. S.
通讯作者：
Lohmander, L. S.
影响因子：
168.9
作者：
Glyn-Jones, S.;Palmer, A. J. R.;Carr, A. J.
通讯作者：
Carr, A. J.
DOI：
10.1083/jcb.98.6.1926
发表时间：
1984-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chiquet M;Fambrough DM
通讯作者：
Fambrough DM