The collaborative study on the genetics of alcoholism: Genetics.
The collaborative study on the genetics of alcoholism: Genetics.
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DOI：
10.1111/gbb.12856
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发表时间：
2023-10
期刊：
影响因子：
--
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中科院分区：
文献类型：
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这篇综述描述了基于家庭的酒精中毒遗传学合作研究（COGA）的遗传学方法和结果。COGA是在连锁时代设计的，旨在识别影响酒精使用障碍（AUD）风险和相关问题的基因，并且是随后采用全基因组关联（GWAS）方法的首批以AUD为重点的研究之一。COGA基于家族的结构，多模式评估与金标准临床和神经生理学数据，以及前瞻性纵向表型的可用性继续为AUD和相关疾病的病因提供见解。这些研究包括对物质使用和使用障碍的遗传风险和轨迹的调查，对感兴趣的基因座的全表型关联研究，以及对多效性、社会基因组学、遗传培养和家庭内比较的调查。COGA是澳大利亚为数不多的包括大量非洲血统参与者的遗传学项目之一。数据和生物标本的共享是COGA项目的基石，COGA是大型GWAS联盟的关键贡献者。COGA丰富的公开遗传和广泛的表型数据继续为我们理解AUD的遗传病因和相关特征提供独特和适应性的资源。COGA的基于家庭的结构，多模式评估与金标准临床和神经生理学数据，以及前瞻性纵向表型的可用性，当结合其GWAS数据时，继续为酒精使用障碍和相关疾病的病因提供见解。COGA丰富的可公开获得的遗传和广泛的表型数据是我们了解酒精使用障碍和相关特征的遗传病因的独特资源。
This review describes the genetic approaches and results from the family‐based Collaborative Study on the Genetics of Alcoholism (COGA). COGA was designed during the linkage era to identify genes affecting the risk for alcohol use disorder (AUD) and related problems, and was among the first AUD‐focused studies to subsequently adopt a genome‐wide association (GWAS) approach. COGA's family‐based structure, multimodal assessment with gold‐standard clinical and neurophysiological data, and the availability of prospective longitudinal phenotyping continues to provide insights into the etiology of AUD and related disorders. These include investigations of genetic risk and trajectories of substance use and use disorders, phenome‐wide association studies of loci of interest, and investigations of pleiotropy, social genomics, genetic nurture, and within‐family comparisons. COGA is one of the few AUD genetics projects that includes a substantial number of participants of African ancestry. The sharing of data and biospecimens has been a cornerstone of the COGA project, and COGA is a key contributor to large‐scale GWAS consortia. COGA's wealth of publicly available genetic and extensive phenotyping data continues to provide a unique and adaptable resource for our understanding of the genetic etiology of AUD and related traits. COGA's family‐based structure, multimodal assessment with gold‐standard clinical and neurophysiological data, and the availability of prospective longitudinal phenotyping, when combined with its GWAS data, continues to provide insights into the etiology of alcohol use disorder and related disorders. COGA's wealth of publicly available genetic and extensive phenotyping data is a unique resource for our understanding of the genetic etiology of alcohol use disorder and related traits.
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影响因子：
2.7
作者：
Su, Jinni;Kuo, Sally I-Chun;Trevino, Angel;Barr, Peter B;Aliev, Fazil;Bucholz, Kathleen;Chan, Grace;Edenberg, Howard J;Kuperman, Samuel;Lai, Dongbing;Meyers, Jacquelyn L;Pandey, Gayathri;Porjesz, Bernice;Dick, Danielle M
通讯作者：
Dick, Danielle M
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
4.2
作者：
Agrawal, Arpana;Hinrichs, Anthony L.;Bierut, Laura J.
通讯作者：
Bierut, Laura J.
影响因子：
2.1
作者：
Chen, Ming-Huei;Liu, Xuan;Wei, Fengrong;Larson, Martin G.;Fox, Caroline S.;Vasan, Ramachandran S.;Yang, Qiong
通讯作者：
Yang, Qiong
DOI：
10.1111/j.1530-0277.2010.01173.x
发表时间：
2010-06
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Chen AC;Manz N;Tang Y;Rangaswamy M;Almasy L;Kuperman S;Nurnberger J Jr;O'Connor SJ;Edenberg HJ;Schuckit MA;Tischfield J;Foroud T;Bierut LJ;Rohrbaugh J;Rice JP;Goate A;Hesselbrock V;Porjesz B
通讯作者：
Porjesz B