Glucose Metabolism Disorder Induces Spermatogenic Dysfunction in Northern Pig-Tailed Macaques (Macaca leonina) With Long-Term SIVmac239 Infection.
Glucose Metabolism Disorder Induces Spermatogenic Dysfunction in Northern Pig-Tailed Macaques (Macaca leonina) With Long-Term SIVmac239 Infection.
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DOI：
10.3389/fendo.2021.745984
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发表时间：
2021
影响因子：
5.2
通讯作者：
Zheng YT
中科院分区：
文献类型：
--
作者：
Song TZ;Zhang MX;Zhang HD;Wang XH;Pang W;Tian RR;Zheng YT
尽管人类免疫缺陷病毒（HIV）患者普遍存在生精功能障碍，但其根本原因仍不清楚。到目前为止，涉及病毒库、睾丸炎症、激素失衡和恶病质的潜在假设与生精功能障碍的相关性不一致。在这里，北方猪尾猕猴（NPM）在长期感染猿猴免疫缺陷病毒（SIVmac239）后表现出明显的生精功能障碍，Johnsen评分、分化的精原干细胞和睾丸增殖细胞显着下降。还对上述假设进行了评估。结果显示，SIV− 和 SIV+ NPM 之间没有差异，除了 SIV 感染期间促卵泡激素 (FSH) 增加，这对睾丸没有直接影响。然而，长期 SIVmac239 感染会破坏胰岛 β 细胞功能，部分表现为细胞计数和自噬水平显着降低。胰岛β细胞功能障碍导致全身糖代谢紊乱，抑制睾丸组织中支持细胞产生乳酸。由于乳酸是生殖细胞发育的主要能量底物，其减少与生精功能障碍密切相关。因此，葡萄糖代谢紊乱似乎是长期感染SIVmac239的NPM生精功能障碍的主要原因。
Although spermatogenic dysfunction is widely found in patients with human immunodeficiency virus (HIV), the underlying reasons remain unclear. Thus far, potential hypotheses involving viral reservoirs, testicular inflammation, hormone imbalance, and cachexia show inconsistent correlation with spermatogenic dysfunction. Here, northern pig-tailed macaques (NPMs) exhibited marked spermatogenic dysfunction after long-term infection with simian immunodeficiency virus (SIVmac239), with significant decreases in Johnsen scores, differentiated spermatogonial stem cells, and testicular proliferating cells. The above hypotheses were also evaluated. Results showed no differences between SIV− and SIV+ NPMs, except for an increase in follicle stimulating hormone (FSH) during SIV infection, which had no direct effect on the testes. However, long-term SIVmac239 infection undermined pancreatic islet β cell function, partly represented by significant reductions in cellular counts and autophagy levels. Pancreatic islet β cell dysfunction led to glucose metabolism disorder at the whole-body level, which inhibited lactate production by Sertoli cells in testicular tissue. As lactate is the main energy substrate for developing germ cells, its decrease was strongly correlated with spermatogenic dysfunction. Therefore, glucose metabolism disorder appears to be a primary cause of spermatogenic dysfunction in NPMs with long-term SIVmac239 infection.
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影响因子：
5.6
作者：
Gong J;Zeng Q;Yu D;Duan YG
通讯作者：
Duan YG
影响因子：
0.8
作者：
BASKERVILLE, A;COOK, RW;GREENAWAY, PJ
通讯作者：
GREENAWAY, PJ
影响因子：
5.9
作者：
DOBS, AS;DEMPSEY, MA;POLK, BF
通讯作者：
POLK, BF
影响因子：
6.6
作者：
Krieger, JN;Nirapathpongporn, A;Coombs, RW
通讯作者：
Coombs, RW
影响因子：
29
作者：
Ebato, Chie;Uchida, Toyoyoshi;Watada, Hirotaka
通讯作者：
Watada, Hirotaka