T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes.
T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes.
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DOI：
10.3390/ijms22010057
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发表时间：
2020-12-23
影响因子：
5.6
通讯作者：
Duan YG
中科院分区：
文献类型：
--
作者：
Gong J;Zeng Q;Yu D;Duan YG
睾丸的免疫特权对于防止对配子特异性抗原和父本主要组织相容性复合体（MHC）抗原的免疫攻击是必要的，从而允许正常的精子发生。然而，男性生殖道的感染和炎症会破坏免疫耐受，是男性不育的一个重要原因。在哺乳动物睾丸中发现了不同的T细胞亚群，它们可能参与睾丸感染和炎症中免疫耐受和致病性免疫反应的维持。我们回顾了已发表的关于人类和动物睾丸中不同T亚型（调节性T细胞、辅助T细胞、细胞毒性T细胞、γδ T细胞和自然杀伤T细胞）在不孕症和睾丸炎病理中的调节作用的文献。虽然许多体外研究已经表明功能性T细胞亚群的调节潜力及其在生理和病理过程中与支持细胞、间质细胞和精子发生的可能相互作用，但迄今为止还没有原位研究。然而，T细胞亚群的正常分布和功能对于睾丸的免疫特权和完整的精子发生至关重要，T细胞介导的免疫反应驱动睾丸炎症。不同T细胞亚群在睾丸稳态和睾丸炎病理中的独特功能表明，针对特定T细胞亚群的治疗具有相当大的潜力，可用于治疗慢性睾丸炎和免疫性不孕。
The immune privilege of the testes is necessary to prevent immune attacks to gamete-specific antigens and paternal major histocompatibility complex (MHC) antigens, allowing for normal spermatogenesis. However, infection and inflammation of the male genital tract can break the immune tolerance and represent a significant cause of male infertility. Different T cell subsets have been identified in mammalian testes, which may be involved in the maintenance of immune tolerance and pathogenic immune responses in testicular infection and inflammation. We reviewed the evidence in the published literature on different T subtypes (regulatory T cells, helper T cells, cytotoxic T cells, γδ T cells, and natural killer T cells) in human and animal testes that support their regulatory roles in infertility and the orchitis pathology. While many in vitro studies have indicated the regulation potential of functional T cell subsets and their possible interaction with Sertoli cells, Leydig cells, and spermatogenesis, both under physiological and pathological processes, there have been no in situ studies to date. Nevertheless, the normal distribution and function of T cell subsets are essential for the immune privilege of the testes and intact spermatogenesis, and T cell-mediated immune response drives testicular inflammation. The distinct function of different T cell subsets in testicular homeostasis and the orchitis pathology suggests a considerable potential of targeting specific T cell subsets for therapies targeting chronic orchitis and immune infertility.
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影响因子：
3.6
作者：
Dal Secco, Valentina;Riccioli, Anna;Filippini, Antonio
通讯作者：
Filippini, Antonio
影响因子：
14.2
作者：
Annunziato, Francesco;Romagnani, Chiara;Romagnani, Sergio
通讯作者：
Romagnani, Sergio
影响因子：
3.4
作者：
Crespo ÂC;van der Zwan A;Ramalho-Santos J;Strominger JL;Tilburgs T
通讯作者：
Tilburgs T
影响因子：
4.4
作者：
Dai, ZH;Nasr, IW;Lakkis, FG
通讯作者：
Lakkis, FG
DOI：
10.15252/embj.201899013
发表时间：
2018-08-15
期刊：
The EMBO journal
影响因子：
--
作者：
Bending D;Paduraru A;Ducker CB;Prieto Martín P;Crompton T;Ono M
通讯作者：
Ono M