Oxidative stress in schizophrenia.
Oxidative stress in schizophrenia.
复制标题
DOI：
10.2174/157015911795596595
复制
发表时间：
2011-06
影响因子：
5.3
通讯作者：
Grabnar I
中科院分区：
文献类型：
--
作者：
Bošković M;Vovk T;Kores Plesničar B;Grabnar I
越来越多的证据表明精神分裂症存在氧化损伤。对氧化应激诱导的可能机制进行了综述。此外，测量的生物标志物的精神分裂症以外的中枢神经系统隔间，其特异性为不同类型的精神分裂症和潜在的治疗策略，以防止氧化损伤的精神分裂症的可能性进行了讨论。数据提取自Medline、Embase、Biosis、科克伦和Web of Science中的已发表文献，并手动检索参考文献。检索词为：精神分裂症、氧化应激、抗精神病药、抗氧化剂和脂肪酸。寻找一种敏感、特异、无创、可在外周组织中检测的精神分裂症生物标志物仍是一项重要任务。抗氧化酶、脂质过氧化标记物、氧化修饰蛋白质和DNA是最常用的。由于它认为补充治疗，根据我们的荟萃分析，维生素E可能会改善迟发性运动障碍，而多不饱和脂肪酸治疗的效果没有明确的证据。氧化应激是精神分裂症的病理学的一部分，并且似乎是开发新的治疗策略的有希望的领域。需要设计良好的安慰剂对照试验，对精神分裂症进行补充治疗。
Increasing evidence indicates that oxidative damage exists in schizophrenia. Available literature about possible mechanisms of oxidative stress induction was reviewed. Furthermore, possibilities of measuring biomarkers of schizophrenia outside the central nervous system compartment, their specificity for different types of schizophrenia and potential therapeutic strategies to prevent oxidative injuries in schizophrenia were discussed. Data were extracted from published literature found in Medline, Embase, Biosis, Cochrane and Web of Science, together with hand search of references. Search terms were: schizophrenia, oxidative stress, antipsychotics, antioxidants and fatty acids. Finding a sensitive, specific and non invasive biomarker of schizophrenia, which could be measured in peripheral tissue, still stays an important task. Antioxidant enzymes, markers of lipid peroxidation, oxidatively modified proteins and DNA are most commonly used. As it considers the supplemental therapy, according to our meta-analysis vitamin E could potentially improve tardive dyskinesia, while for the effect of therapy with polyunsaturated fatty acids there is no clear evidence. Oxidative stress is a part of the pathology in schizophrenia and appears as a promising field to develop new therapeutic strategies. There is a need for well designed, placebo controlled trials with supplementation therapy in schizophrenia.
登录
查看更多内容
影响因子：
3.1
作者：
Bulut, Mahmut;Savas, Haluk Asuman;Dalkilic, Alican
通讯作者：
Dalkilic, Alican
影响因子：
4.7
作者：
BENSHACHAR, D;ZUK, R;GLINKA, Y
通讯作者：
GLINKA, Y
影响因子：
4.5
作者：
Arvindakshan, M;Ghate, M;Mahadik, SP
通讯作者：
Mahadik, SP
影响因子：
7.4
作者：
Buss, H;Chan, TP;Winterbourn, CC
通讯作者：
Winterbourn, CC
影响因子：
3.2
作者：
Dakhale, G;Khanzode, S;Turankar, A
通讯作者：
Turankar, A