Oxytocin induces a conditioned social preference in female mice.
Oxytocin induces a conditioned social preference in female mice.
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DOI：
10.1111/jne.12075
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发表时间：
2013-09
影响因子：
3.2
通讯作者：
Wood RI
中科院分区：
文献类型：
--
作者：
Kent K;Arientyl V;Khachatryan MM;Wood RI
在人类和许多社会性哺乳动物中，友谊和其他有益的亲密关系与九肽激素催产素（OT）的作用有关。我们确定OT本身是否是奖励的，如果奖励取决于同种的存在。我们评估了OT输注对雌性小鼠社会性（条件性社会偏好，CSP）和非社会性测试（条件性位置偏好，CPP）的强化作用。切除卵巢的雌性动物接受雌二醇植入和脑室内插管。在预测试期间，将它们引入3室装置10分钟。社会和地方装置是相同的，除了每个端室包含一个新的刺激女性CSP，而他们区分的视觉和触觉线索CPP。对于CSP，试验雌性接受OT（0、100、200或100 ng），并与一只刺激雌性配对30分钟。隔日，它们接受生理盐水溶剂，并与对侧雌性配对，每组共4对。最终的条件偏好测试与前测试相同。OT诱导CSP。接受100 ng OT的实验小鼠在条件偏好测试期间的偏好评分从测试前的-67.4 ±22.1秒增加到+55.7 35. 1秒（p<0.05）。200 ng OT诱导偏好评分从−162.7±47.3增加到+74.3 23. 7秒（p <0.001）。0和1000 ng OT对CSP无影响。在200 ng OT下测试另外一组小鼠的CPP。测试和配对与CSP相同。OT诱导小但显著的CPP。小鼠的偏好评分从-222.4 ±38.0秒增加到-126.0 ±58.7秒（p<0.05）。OT对焦虑或气味识别没有影响，分别通过高架十字迷宫和嗅觉习惯化/disabituation测试进行评估。总之，OT像其他激励刺激（药物，食物）是奖励时，测试在孤独的条件下，但也加强在社会环境中。
Friendships and other rewarding affilliative bonds are associated with the actions of the nonapeptide hormone oxytocin (OT) in humans and many social mammals. We determined if OT itself is rewarding, and if that reward is dependent upon the presence of conspecifics. We evaluated the reinforcing effects of OT infusion in female mice on social (conditioned social preference, CSP), and non-social tests (conditioned place preference, CPP). Ovariectomised females received oestradiol implants and intracerebroventricular cannulas. During a pre-test, they were introduced to a 3-chamber apparatus for 10 minutes. Social and place apparatus were identical, except that each end-chamber contained a novel stimulus female for CSP, whereas they were distinguished by visual and tactile cues for CPP. For CSP, test females received OT (0, 100, 200 or 100ng) and were paired for 30 minutes with one stimulus female. On alternating days, they received saline vehicle and were paired with the opposite female, for a total of 4 pairings each. The final conditioned preference test was identical to the pre-test. OT induced CSP. Test mice that received 100ng OT increased their preference score from −67.4±22.1 seconds in pre-test to +55.7±35.1 seconds during the conditioned preference test (p<0.05). 200ng OT induced an increase in preference score from −162.7±47.3 to +74.3±23.7 seconds (p <0.001). There was no effect of 0 or 1000ng OT on CSP. An additional group of mice was tested for CPP at 200ng OT. Testing and pairings were identical to CSP. OT induced a small but significant CPP. Mice increased their preference score from −222.4±38.0 to −126.0±58.7 seconds (p<0.05). OT had no effect on anxiety or odor recognition as assessed by elevated plus maze and olfactory habituation/dishabituation tests, respectively. In conclusion, OT like other motivating stimuli (drugs, food) is rewarding when tested under solitary conditions, but is also reinforcing in a social setting.
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