Learning from biology: synthetic lipoproteins for drug delivery.
Learning from biology: synthetic lipoproteins for drug delivery.
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DOI：
10.1002/wnan.1308
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发表时间：
2015-05
影响因子：
8.6
通讯作者：
Zheng, Gang
中科院分区：
文献类型：
--
作者：
Huang, Huang;Cruz, William;Chen, Juan;Zheng, Gang
合成脂蛋白是将生物/化学试剂（化疗药物、siRNA、光敏剂和成像造影剂）靶向递送至各种细胞类型的相关工具。这些纳米颗粒在药物输送方面比天然纳米颗粒具有许多优势，同时保留了其天然特性和生物功能。它们的超小尺寸（<30nm）、高生物相容性、良好的循环半衰期以及结合特定脂蛋白受体（即低密度脂蛋白受体（LDLR）和清道夫受体B类成员1（SRB1）的天然能力，这些受体存在于许多病理状况（例如癌症、动脉粥样硬化）中），使它们与其他纳米颗粒系统相比成为优越的递送策略。我们回顾了已开发的用于生成合成脂蛋白的各种方法及其各自的体外和体内应用。更具体地说，我们总结了通过天然或重组载脂蛋白以及载脂蛋白模拟分子来解决重组脂蛋白使用限制的方法。最后，我们概述了这些方法的优点和缺点，并讨论了这些纳米颗粒临床转化的未来前景。
Synthetic lipoproteins represent a relevant tool for targeted delivery of biological/chemical agents (chemotherapeutics, siRNAs, photosensitizers and imaging contrast agents) into various cell types. These nanoparticles offer a number of advantages on drugs delivery over their native counterparts while retaining their natural characteristics and biological functions. Their ultra-small size (<30nm), high biocompatibility, favorable circulation half-life and natural ability to bind specific lipoprotein receptors i.e. low-density lipoprotein receptor (LDLR) and Scavenger receptor class B member 1 (SRB1) that are found in a number of pathological conditions (e.g. cancer, atherosclerosis), make them superior delivery strategies when compared to other nanoparticle systems. We review the various approaches that have been developed for the generation of synthetic lipoproteins and their respective applications in vitro and in vivo. More specifically, we summarize the way to address the limitation on use of reconstituted lipoproteins by means of natural or recombinant apolipoproteins, as well as apolipoprotein mimetic molecules. Finally, we provide an overview of the advantages and disadvantages of these approaches and discuss future perspectives for clinical translation of these nanoparticles.
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