Production of interleukin-27 by human neutrophils regulates their function during bacterial infection.
Production of interleukin-27 by human neutrophils regulates their function during bacterial infection.
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DOI：
10.1002/eji.201242526
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发表时间：
2012-12
影响因子：
5.4
通讯作者：
Lertmemongkolchai, Ganjana
中科院分区：
文献类型：
--
作者：
Rinchai, Darawan;Khaenam, Prasong;Kewcharoenwong, Chidchamai;Buddhisa, Surachat;Pankla, Rungnapa;Chaussabel, Damien;Bancroft, Gregory J.;Lertmemongkolchai, Ganjana
Septicemia is the most severe form of melioidosis caused by the Gram-negative bacterium, Burkholderia pseudomallei. Here, we showed that levels of IL-27p28 transcript and protein were both significantly elevated in patients with sepsis, particularly melioidosis and in patients with unfavorable disease outcome. Moreover, monocytes/macrophages and neutrophils were the major source of IL-27 during infection. Addition of exogenous IL-27 in vitro resulted in significantly increased bacterial survival, reduced B. pseudomallei-induced oxidative burst and enhanced IL-1beta and TNF-alpha production by purified neutrophils from healthy subjects. Finally, blockade of endogenous IL-27 in neutrophils using soluble IL-27 receptor antagonist prior to infection led to significantly reduced survival of bacteria and decreased IL-1beta, but not TNF-alpha production. These results indicate a potential role of IL-27 in suppression of antibacterial defense mechanisms that might contribute to disease severity in sepsis. The targeting of this cytokine may be beneficial in the management of human sepsis.
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影响因子：
15.3
作者：
Liu, Jianguo;Guan, Xiuqin;Ma, Xiaojing
通讯作者：
Ma, Xiaojing
影响因子：
3.1
作者：
Chanchamroen, Sujin;Kewcharoenwong, Chidchamai;Lertmemongkolchai, Ganjana
通讯作者：
Lertmemongkolchai, Ganjana
影响因子：
32.4
作者：
Pflanz, S;Timans, JC;Kastelein, RA
通讯作者：
Kastelein, RA
影响因子：
100.3
作者：
Goriely, Stanislas;Neurath, Markus F.;Goldman, Michel
通讯作者：
Goldman, Michel
影响因子：
6.4
作者：
Haque, Ashraful;Chu, Karen;Bancroft, Gregory J.
通讯作者：
Bancroft, Gregory J.