Drug release kinetics and transport mechanisms from semi-interpenetrating networks of gelatin and poly(ethylene glycol) diacrylate.
Drug release kinetics and transport mechanisms from semi-interpenetrating networks of gelatin and poly(ethylene glycol) diacrylate.
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DOI：
10.1007/s11095-009-9923-1
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发表时间：
2009-09
影响因子：
3.7
通讯作者：
Kao WJ
中科院分区：
文献类型：
--
作者：
Fu Y;Kao WJ
研究了部分交联、可溶胀、可生物降解的聚乙二醇二丙烯酸酯(PEGdA)和明胶组成的半互穿网络(SIPN)中影响溶质迁移的关键参数。考察了材料组成、溶质大小、溶解度和装载密度等因素的影响。制备了明胶/PEGdA重量比为10：15、10：20、10：30、15：15、20：15的SIPN。选择了5种不同物理化学性质的模型溶液，即磺胺嘧啶银(AgSD)、盐酸布比卡因(Bup)、磺胺嘧啶钠(NASD)、角质形成细胞生长因子(KGF)和牛血清白蛋白-异硫氰酸荧光素(BSA-FITC)。采用三种常见的水凝胶理论(自由体积理论、流体力学理论和阻滞性理论)进行释药研究，并对结果进行分析。考察了各因素对模型溶质释放动力学的影响。具体来说，初始释放速率和凝胶内扩散系数随PEGdA含量的增加或溶质分子量的增加而降低。然而，随着明胶含量的增加或溶质水溶解度的增加，凝胶的初始释放速率和凝胶内扩散系数增加，这与经典的基于水凝胶的溶质传输理论相矛盾，即增加聚合物体积会导致溶质在凝胶内的扩散系数降低。这一分析提供了sIPN的结构-功能信息，作为潜在的治疗递送基质。
To elucidate the key parameters affecting solute transport from semi-interpenetrating networks (sIPNs) comprised of poly(ethylene glycol) diacrylate (PEGdA) and gelatin that are partially crosslinked, water-swellable and biodegradable. Effects of material compositions, solute size, solubility, and loading density have been investigated. sIPNs of following gelatin/PEGdA weight-to-weight ratios were prepared: 10:15, 10:20, 10:30, 15:15, 20:15. Five model solutes of different physicochemical properties were selected, i.e. silver sulfadiazine (AgSD), bupivacaine hydrochloride (Bup), sulfadiazine sodium (NaSD), keratinocyte growth factor (KGF), and bovine serum albumin conjugated with fluorescein isothiocyanate (BSA-FITC). Release studies were performed and the results were analyzed using three hydrogel based common theories (free volume, hydrodynamic and obstruction). The release kinetics of model solutes was influenced by each factor under investigation. Specifically, the initial release rates and intra-gel diffusivity decreased with increasing PEGdA content or increasing solute molecular weight. However, the initial release rate and intra-gel diffusivity increased with increasing gelatin content or increasing solute water solubility, which contradicted with the classical hydrogel based solute transport theories, i.e. increasing polymer volume leads to decreased solute diffusivity within the gel. This analysis provides structure-functional information of the sIPN as a potential therapeutic delivery matrix.
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影响因子：
3.7
作者：
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通讯作者：
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