Noise driven evolutionary waves.
Noise driven evolutionary waves.
复制标题
DOI：
10.1371/journal.pcbi.1002005
复制
发表时间：
2011-03
影响因子：
4.3
通讯作者：
Hallatschek O
中科院分区：
文献类型：
--
作者：
Hallatschek O
空间扩展种群的适应需要跨越栖息地范围传播进化的新奇事物。在自然选择的驱动下，有益的突变以“前进的浪潮”席卷整个种群。这些行波的标准模型，由于R。Fisher和A. Kolmogorov，在许多科学领域发挥着重要作用，除了进化，如生态学，流行病学，化学动力学，最近甚至在粒子物理学。在这里，我们扩展了Fisher-Kolmogorov模型，以解释赋予人口密度增加的突变，例如由于代谢效率的提高。我们表明，这些突变入侵的随机遗传漂变的行动，即使突变是轻微有害的。随后一类噪声驱动波的特征是波速随着人口规模的增加而降低，这与传统的费舍尔-科尔莫戈罗夫波相反。当密度和增长率之间存在权衡时，可以预测进化的最优种群密度。我们的模拟和分析结果表明，遗传漂变与空间结构相结合，促进了有限资源的经济利用。我们的模型很简单，没有任何复杂的个体之间的相互作用，这表明噪音诱导的模式形成可能出现在许多复杂的生物系统中，包括进化。增加有机体适应性的突变是生物进化的燃料。当这种有益的突变进入一个空间扩展的群体时，它们在群体中以“前进的浪潮”传播，这首先由R。Fisher和A.哥洛夫驱动这些行波的力量是达尔文选择，它有利于具有更高适应性的个体。在这里，我们描述了一种新型的旅行突变波，它是由非选择性力量驱动的-即随机遗传漂变，指的是繁殖过程中的随机性。这些噪音驱动的波浪促进了有限资源的经济利用，因为每当突变增加生长产量时，它们就会发生，生长产量是指每单位资源产生的生物量。由于生长产量和生长速率的变化经常同时发生，并且具有相反的迹象，因此我们认为这两种类型的机制将共同决定新突变的命运。我们预测，人口演变的进化最优承载能力，在选择性和非选择性的力量刚刚平衡。
Adaptation in spatially extended populations entails the propagation of evolutionary novelties across habitat ranges. Driven by natural selection, beneficial mutations sweep through the population in a “wave of advance”. The standard model for these traveling waves, due to R. Fisher and A. Kolmogorov, plays an important role in many scientific areas besides evolution, such as ecology, epidemiology, chemical kinetics, and recently even in particle physics. Here, we extend the Fisher–Kolmogorov model to account for mutations that confer an increase in the density of the population, for instance as a result of an improved metabolic efficiency. We show that these mutations invade by the action of random genetic drift, even if the mutations are slightly deleterious. The ensuing class of noise-driven waves are characterized by a wave speed that decreases with increasing population sizes, contrary to conventional Fisher–Kolmogorov waves. When a trade-off exists between density and growth rate, an evolutionary optimal population density can be predicted. Our simulations and analytical results show that genetic drift in conjunction with spatial structure promotes the economical use of limited resources. The simplicity of our model, which lacks any complex interactions between individuals, suggests that noise-induced pattern formation may arise in many complex biological systems including evolution. Mutations that increase an organism's fitness are the fuel for biological evolution. When such beneficial mutations enter a spatially extended population, they spread through the population in a “wave of advance”, first described by R. Fisher and A. Kolmogorov. The force driving these traveling waves is Darwinian selection, which favors individuals with higher fitness. Here, we describe a new type of traveling mutant wave that is driven by non-selective forces instead-- namely by random genetic drift, which refers to the randomness in the reproduction process. These noise-driven waves promote the economical use of a limited resource because they occur whenever a mutation increases the growth yield, which refers to the biomass produced per unit of resource. Since a change in growth yield and growth rate often occur together and with opposite signs, we argue that both types of mechanisms will jointly decide over the fate of a novel mutation. We predict that the population evolves towards an evolutionary optimal carrying capacity, at which selective and non-selective forces just balance.
登录
查看更多内容
影响因子：
3.3
作者：
Matsushita, M;Wakita, J;Mimura, M
通讯作者：
Mimura, M
DOI：
10.1073/pnas.0702207104
发表时间：
2007-05-15
影响因子：
11.1
作者：
Lynch, Michael
通讯作者：
Lynch, Michael
影响因子：
2
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
影响因子：
1.4
作者：
Barton, NH;Depaulis, F;Etheridge, AM
通讯作者：
Etheridge, AM
影响因子：
0.8
作者：
COLE, JD
通讯作者：
COLE, JD