Experimental 'jet lag' inhibits adult neurogenesis and produces long-term cognitive deficits in female hamsters.
Experimental 'jet lag' inhibits adult neurogenesis and produces long-term cognitive deficits in female hamsters.
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DOI：
10.1371/journal.pone.0015267
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发表时间：
2010-12-01
期刊：
影响因子：
3.7
通讯作者：
Kriegsfeld LJ
中科院分区：
文献类型：
--
作者：
Gibson EM;Wang C;Tjho S;Khattar N;Kriegsfeld LJ
通过频繁的跨子午线旅行、轮班工作和睡眠卫生不良造成的昼夜节律紊乱与一系列身心健康疾病有关，包括人类认知功能的明显缺陷。尽管有轶事和相关报道表明昼夜节律紊乱对大脑功能有负面影响，但这种可能性尚未得到实验验证。在本研究中，我们调查了实验性的“时差”（即，光∶暗周期的相位进展）对学习和记忆产生负面影响，以及观察到的任何缺陷是否与海马细胞增殖和神经发生的减少有关。由于昼夜节律的侮辱改变循环糖皮质激素和性类固醇的浓度，这两者都影响神经发生和学习/记忆，我们评估了这些内分泌因素的任何观察到的变化的贡献。昼夜节律紊乱导致学习和记忆的明显缺陷，海马细胞增殖和神经发生明显减少。值得注意的是，依赖于昼夜节律的学习和记忆的缺陷不仅出现在昼夜节律中断期间，而且在时差停止后仍然存在，这表明对大脑功能的长期负面影响。总之，这些研究结果支持这样的观点，即昼夜节律中断通过糖皮质激素非依赖性机制抑制海马神经发生，对学习和记忆造成明显和持久的损害。
Circadian disruptions through frequent transmeridian travel, rotating shift work, and poor sleep hygiene are associated with an array of physical and mental health maladies, including marked deficits in human cognitive function. Despite anecdotal and correlational reports suggesting a negative impact of circadian disruptions on brain function, this possibility has not been experimentally examined. In the present study, we investigated whether experimental ‘jet lag’ (i.e., phase advances of the light∶dark cycle) negatively impacts learning and memory and whether any deficits observed are associated with reductions in hippocampal cell proliferation and neurogenesis. Because insults to circadian timing alter circulating glucocorticoid and sex steroid concentrations, both of which influence neurogenesis and learning/memory, we assessed the contribution of these endocrine factors to any observed alterations. Circadian disruption resulted in pronounced deficits in learning and memory paralleled by marked reductions in hippocampal cell proliferation and neurogenesis. Significantly, deficits in hippocampal-dependent learning and memory were not only seen during the period of the circadian disruption, but also persisted well after the cessation of jet lag, suggesting long-lasting negative consequences on brain function. Together, these findings support the view that circadian disruptions suppress hippocampal neurogenesis via a glucocorticoid-independent mechanism, imposing pronounced and persistent impairments on learning and memory.
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影响因子：
3.2
作者：
Barha, C. K.;Lieblich, S. E.;Galea, L. A. M.
通讯作者：
Galea, L. A. M.
影响因子：
3.3
作者：
Barker, J. M.;Galea, L. A. M.
通讯作者：
Galea, L. A. M.
DOI：
10.1007/s00420-001-0299-8
发表时间：
2002-04-01
影响因子：
3
作者：
Bildt, C;Michélsen, H
通讯作者：
Michélsen, H
影响因子：
2.9
作者：
Cain, SW;Karatsoreos, I;Ralph, MR
通讯作者：
Ralph, MR
影响因子：
3.5
作者：
Daniel, JM;Fader, AJ;Dohanich, GP
通讯作者：
Dohanich, GP