Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD.
Atrial Fibrillation and Longitudinal Change in Cognitive Function in CKD.
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DOI：
10.1016/j.ekir.2020.12.023
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发表时间：
2021-03
影响因子：
6
通讯作者：
CRIC Study Investigators
中科院分区：
文献类型：
--
作者：
McCauley MD;Hsu JY;Ricardo AC;Darbar D;Kansal M;Kurella Tamura M;Feldman HI;Kusek JW;Taliercio JJ;Rao PS;Shafi T;He J;Wang X;Sha D;Lamar M;Go AS;Yaffe K;Lash JP;CRIC Study Investigators
针对普通人群的研究表明，心房颤动 (AF) 是认知功能下降的独立危险因素，但这种关系尚未在患有慢性肾病 (CKD) 的成人中得到检验。我们研究了该人群中房颤事件与认知功能随时间变化之间的关联。我们对参与慢性肾功能不全队列研究的 3254 名成年人进行了研究。房颤事件是通过研究访视时获得的 12 导联心电图 (ECG) 和/或随访期间确定房颤住院情况来确定的。使用改良的简易精神状态检查每两年评估一次认知功能。线性混合效应回归用于评估房颤事件与认知功能纵向变化之间的关联。与没有发生 AF 的个体 (n = 3158) 相比，发生 AF 的个体 (n = 96) 年龄更大，心血管疾病和高血压的患病率更高，估计肾小球滤过率更低。经过中位随访 6.8 年，我们观察到房颤事件与认知功能测试分数变化之间没有显着的多变量关联。在这组患有 CKD 的成年人中，发生 AF 与认知功能下降无关。
Studies in the general population suggest that atrial fibrillation (AF) is an independent risk factor for decline in cognitive function, but this relationship has not been examined in adults with chronic kidney disease (CKD). We investigated the association between incident AF and changes in cognitive function over time in this population. We studied a subgroup of 3254 adults participating in the Chronic Renal Insufficiency Cohort Study. Incident AF was ascertained by 12-lead electrocardiogram (ECG) obtained at a study visit and/or identification of a hospitalization with AF during follow-up. Cognitive function was assessed biennially using the Modified Mini-Mental State Exam. Linear mixed effects regression was used to evaluate the association between incident AF and longitudinal change in cognitive function. Compared with individuals without incident AF (n = 3158), those with incident AF (n = 96) were older, had a higher prevalence of cardiovascular disease and hypertension, and lower estimated glomerular filtration rate. After median follow-up of 6.8 years, we observed no significant multivariable association between incident AF and change in cognitive function test score. In this cohort of adults with CKD, incident AF was not associated with a decline in cognitive function.
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影响因子：
2.1
作者：
Zammit, Andrea R.;Katz, Mindy J.;Lipton, Richard B.
通讯作者：
Lipton, Richard B.
DOI：
10.2215/cjn.04060318
发表时间：
2018-09-07
影响因子：
9.8
作者：
Carrero, Juan Jesus;Trevisan, Marco;Szummer, Karolina
通讯作者：
Szummer, Karolina
影响因子：
6.3
作者：
Yaffe K;Ackerson L;Kurella Tamura M;Le Blanc P;Kusek JW;Sehgal AR;Cohen D;Anderson C;Appel L;Desalvo K;Ojo A;Seliger S;Robinson N;Makos G;Go AS;Chronic Renal Insufficiency Cohort Investigators
通讯作者：
Chronic Renal Insufficiency Cohort Investigators
影响因子：
4.8
作者：
Soliman EZ;Prineas RJ;Go AS;Xie D;Lash JP;Rahman M;Ojo A;Teal VL;Jensvold NG;Robinson NL;Dries DL;Bazzano L;Mohler ER;Wright JT;Feldman HI;Chronic Renal Insufficiency Cohort (CRIC) Study Group
通讯作者：
Chronic Renal Insufficiency Cohort (CRIC) Study Group
影响因子：
13.2
作者：
Drew, David A.;Weiner, Daniel E.;Sarnak, Mark J.
通讯作者：
Sarnak, Mark J.