MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction.

MCDB: A comprehensive curated mitotic catastrophe database for retrieval, protein sequence alignment, and target prediction.
复制标题

MCDB:一个综合性的有丝分裂灾难数据库,用于检索、蛋白质序列比对和目标预测

DOI:
10.1016/j.apsb.2021.05.032
复制
发表时间:
2021-10
期刊:
Acta pharmaceutica Sinica. B
影响因子:
--
通讯作者:
Ouyang L
Ouyang L
中科院分区:
其他
文献类型:
--
作者:
Zhang L;Zhang L;Guo Y;Xiao M;Feng L;Yang C;Wang G;Ouyang L

文献摘要

参考文献

被引文献

相似文献

有丝分裂灾难(Mitotic catastrophe,MC)是由有丝分裂过程紊乱引起的细胞程序性死亡,在肿瘤的预防、发展和耐药中具有重要意义。由于MC数据的迅速增加正在大力推动肿瘤相关的生物医学和临床研究,因此迫切需要建立一个专业和全面的MC数据库来整理MC相关数据。有丝分裂灾难数据库(MCDB)包括从8000多篇研究文章中收集和组织的1214个基因/蛋白质和5014个化合物。此外,MCDB定义了与MC相关的数据的置信度、分类标准和统一的命名规则,大大提高了数据的可靠性和检索的方便性。此外,MCDB还开发了蛋白质序列比对和靶标预测功能。前者可用于预测新的潜在MC相关基因和蛋白,后者可用于鉴定未知MC相关化合物的潜在靶蛋白。MCDB是一个专有的、标准的、全面的MC相关数据库,它将促进从化学家到生物学家在药物化学、分子生物学、生物信息学、肿瘤学等领域对MC的探索。http://www.combio-lezhang.online/MCDB/index_html/ MCDB是一个专有的,标准的,全面的有丝分裂灾难(MC)相关数据库,将促进从化学家到生物学家在药物化学,分子生物学,生物信息学,肿瘤学等领域的MC探索。
Mitotic catastrophe (MC) is a form of programmed cell death induced by mitotic process disorders, which is very important in tumor prevention, development, and drug resistance. Because rapidly increased data for MC is vigorously promoting the tumor-related biomedical and clinical study, it is urgent for us to develop a professional and comprehensive database to curate MC-related data. Mitotic Catastrophe Database (MCDB) consists of 1214 genes/proteins and 5014 compounds collected and organized from more than 8000 research articles. Also, MCDB defines the confidence level, classification criteria, and uniform naming rules for MC-related data, which greatly improves data reliability and retrieval convenience. Moreover, MCDB develops protein sequence alignment and target prediction functions. The former can be used to predict new potential MC-related genes and proteins, and the latter can facilitate the identification of potential target proteins of unknown MC-related compounds. In short, MCDB is such a proprietary, standard, and comprehensive database for MC-relate data that will facilitate the exploration of MC from chemists to biologists in the fields of medicinal chemistry, molecular biology, bioinformatics, oncology and so on. The MCDB is distributed on http://www.combio-lezhang.online/MCDB/index_html/. MCDB is a proprietary, standard, and comprehensive database for mitotic catastrophe (MC)-relate data that will facilitate the exploration of MC from chemists to biologists in the fields of medicinal chemistry, molecular biology, bioinformatics, oncology and so on.
DOI: 10.1093/nar/gky1055
发表时间: 2019-01-08
影响因子: 14.9
作者:
The Gene Ontology Consortium
通讯作者: The Gene Ontology Consortium
自噬化合物数据库:连接自噬调节化合物、其潜在靶标和相关疾病的资源
DOI: 10.1111/cpr.12403
发表时间: 2018-06-01
期刊: CELL PROLIFERATION
影响因子: 8.5
作者:
Deng, Yiqi;Zhu, Lingjuan;Liu, Bo
通讯作者: Liu, Bo
DOI: 10.1021/ci9803381
发表时间: 1999-07-01
期刊: JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES
影响因子: --
作者:
Butina, D
通讯作者: Butina, D
DOI: 10.1002/1878-0261.12756
发表时间: 2020-10
期刊: Molecular oncology
影响因子: 6.6
作者:
Drápela S;Khirsariya P;van Weerden WM;Fedr R;Suchánková T;Búzová D;Červený J;Hampl A;Puhr M;Watson WR;Culig Z;Krejčí L;Paruch K;Souček K
通讯作者: Souček K
DOI: 10.1186/s13321-015-0069-3
发表时间: 2015
影响因子: 8.6
作者:
Bajusz D;Rácz A;Héberger K
通讯作者: Héberger K