Endometrial Glandular Dysplasia (EmGD): morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers.

Endometrial Glandular Dysplasia (EmGD): morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers.
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子宫内膜腺发育不良(EMGD):II型子宫内膜癌的形态和生物学上独特的假定前体病变。

DOI:
10.1186/1746-1596-3-6
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发表时间:
2008-02-08
影响因子:
2.6
通讯作者:
Zheng, Wenxin
Zheng, Wenxin
中科院分区:
医学4区
文献类型:
--
作者:
Fadare, Oluwole;Zheng, Wenxin

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在本文中,作者简要回顾了 II 型子宫内膜癌的各种假定前驱病变的历史演变,重点是新定义的“子宫内膜腺体发育不良 (EmGD)”。详细回顾了将浆液性 EmGD 描述为子宫内膜浆液性癌最可能的前驱病变的证据基础。有人提出了关于停止使用浆液性“子宫内膜上皮内癌(EIC)”这一术语作为对所谓的上皮内癌前病变的描述的争论。初步证据还表明,存在一种形态学上可识别的“透明细胞 EmGD”,它可能代表子宫内膜透明细胞癌的癌前病变。
In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.
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