High Salt Diet Sensitizes Cardiopulmonary Baroreflexes in Dahl Salt‐Resistant Rats
High Salt Diet Sensitizes Cardiopulmonary Baroreflexes in Dahl Salt‐Resistant Rats
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高盐饮食使达尔耐盐大鼠的心肺压力反射敏感
DOI：
10.1161/01.hyp.8.6_pt_2.ii21
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发表时间：
1986
期刊：
影响因子：
8.3
通讯作者：
A. Mark
中科院分区：
文献类型：
--
作者：
R. Victor;D. Morgan;P. Thoren;A. Mark
与达尔耐盐(R)大鼠相比，低盐饮食的达尔盐敏感(S)大鼠的交感神经活动的心肺气压反射控制受损。本研究的目的是检测两种Dahl大鼠在高盐饮食刺激下心肺压力反射功能的敏感性。我们研究了低盐和高盐饮食6周后的Dahl R和S大鼠。为了评估心肺压力反射功能，我们测量了双侧窦主动脉去神经支配后，在分级容积扩张（葡聚糖75）期间左心室舒张末压升高所产生的内脏交感神经活动的减少。在低盐和高盐饮食组中，给定的输注量使达尔R大鼠左心室舒张末压升高，但高盐组交感神经活动的降低明显大于低盐组。因此，高盐饮食增强了Dahl R大鼠对体积扩张的交感抑制反应。相比之下，在达尔S大鼠中，容积扩张时左室舒张末压的等效升高在高盐组中产生的交感神经抑制反应小于低盐组。以左心室舒张末期压每毫米汞柱升高时交感神经活动减少百分比表示的心肺压力反射的增加，在达尔R大鼠中，高盐饮食显著增加，而在达尔S大鼠中，高盐饮食倾向于降低。综上所述，本研究表明高盐饮食对Dahl R大鼠的心肺气压反射有增敏作用，而对Dahl S大鼠无增敏作用。我们认为，高盐饮食对Dahl R大鼠交感神经流出反射抑制的增强可能对盐性高血压的发生具有保护作用。相反，Dahl S大鼠的压力反射功能缺乏这种代偿性增强可能有助于盐敏感性。
Compared with Dahl salt-resistant (R) rats, Dahl salt-sensitive (S) rats on a low salt diet have impaired cardiopulmonary baroreflex control of sympathetic nerve activity. The purpose of this study was to examine the sensitivity of cardiopulmonary baroreflex function in both strains of Dahl rats when they are challenged with a high salt diet. We studied Dahl R and S rats after 6 weeks of low and high salt diets. To assess cardiopulmonary baroreflex function, we measured decreases in splanchnic sympathetic nerve activity produced by increases in left ventricular end-diastolic pressure during graded volume expansion (dextran 75) after bilateral sinoaortic denervation. A given amount of infused volume produced comparable increases in left ventricular end-diastolic pressure in Dahl R rats on low and high salt diets but significantly greater decreases in sympathetic nerve activity in the high salt group than in the low salt group. Thus, the high salt diet augmented the sympathoinhibitory response to volume expansion in the Dahl R rats. In contrast, among the Dahl S rats equivalent increases in left ventricular end-diastolic pressure during volume expansion produced smaller sympathoinhibitory responses in the high salt group than in the low salt group. The gain of the cardiopulmonary baroreflex, expressed as the percentage decrease in sympathetic nerve activity per mm Hg increase in left ventricular end-diastolic pressure, was significantly increased by a high salt diet in Dahl R rats but tended to be decreased by a high salt diet in Dahl S rats. In conclusion, this study demonstrates that a high salt diet sensitizes the cardiopulmonary baroreflex in Dahl R rats but not in Dahl S rats. We suggest that this augmentation in the reflex restraint of sympathetic neural outflow in Dahl R rats on a high salt diet may exert a protective effect against the development of salt-induced hypertension. Conversely, the lack of this compensatory augmentation in baroreflex function in Dahl S rats might contribute to salt sensitivity.
达尔株遗传性高血压中动脉肌膜特性未改变。
DOI：
10.1152/ajpheart.1981.241.2.h224
发表时间：
1981
期刊：
The American journal of physiology
影响因子：
--
作者：
Abel,PW;Trapani,A;Matsuki,N;Ingram,MJ;Ingram,FD;Hermsmeyer,K
通讯作者：
Hermsmeyer,K
低盐饮食喂养的达尔盐敏感大鼠左心房感觉末梢的初步重置。
DOI：
10.1152/ajpheart.1987.253.1.h133
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
Thoren,P;Morgan,DA;Mark,AL
通讯作者：
Mark,AL