Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): an emerging signaling molecule.
Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): an emerging signaling molecule.
复制标题
DOI：
10.1016/j.plipres.2009.12.003
复制
发表时间：
2010-07
影响因子：
13.6
通讯作者：
Papadopoulos, Vassilios
中科院分区：
文献类型：
--
作者：
Fan, Jinjiang;Liu, Jun;Culty, Martine;Papadopoulos, Vassilios
高尔基体介导的信号传导与其在细胞有丝分裂周期期间的断裂和再生有关。在此过程中，高尔基体驻留蛋白被释放到细胞质中并与其他信号分子相互作用以调节各种细胞过程。含有酰基辅酶 A 结合域 3 的蛋白 (ACBD3) 是一种参与多种信号转导事件的高尔基体蛋白。 ACBD3 蛋白以前被称为外周型苯二氮卓受体和 cAMP 依赖性蛋白激酶相关蛋白 7 (PAP7)、60 kDa 高尔基复合体相关蛋白 (GCP60)、高尔基复合体相关蛋白 1 (GOCAP1) 和高尔基体磷蛋白 1 (GOLPH1)。在这篇综述中，我们介绍了 ACBD3 的基因本体、它与其他酰基辅酶 A 结合蛋白 (ACBP) 结构域的蛋白质的关系，以及它在类固醇生成、细胞凋亡、神经发生和胚胎发生中的生物学功能。我们还讨论了 ACBD3 在不对称细胞分裂和癌症中的作用。关于 ACBD3 的新发现可能有助于理解这种新表征的信号分子，并刺激对其在分子内分泌学、神经学和干细胞生物学中的作用的进一步研究。
Golgi body-mediated signaling has been linked to its fragmentation and regeneration during the mitotic cycle of the cell. During this process, Golgi-resident proteins are released to the cytosol and interact with other signaling molecules to regulate various cellular processes. Acyl-coenzyme A binding domain containing 3 protein (ACBD3) is a Golgi protein involved in several signaling events. ACBD3 protein was previously known as peripheral-type benzodiazepine receptor and cAMP-dependent protein kinase associated protein 7 (PAP7), Golgi complex-associated protein of 60 kDa (GCP60), Golgi complex-associated protein 1 (GOCAP1), and Golgi phosphoprotein 1 (GOLPH1). In this review, we present the gene ontology of ACBD3, its relations to other Acyl-coenzyme A binding protein (ACBP) domain containing proteins, and its biological function in steroidogenesis, apoptosis, neurogenesis, and embryogenesis. We also discuss the role of ACBD3 in asymmetric cell division and cancer. New findings about ACBD3 may help understand this newly characterized signaling molecule and stimulate further research into its role in molecular endocrinology, neurology, and stem cell biology.
登录
查看更多内容
影响因子：
4.1
作者：
Burton, M;Rose, TM;Knudsen, J
通讯作者：
Knudsen, J
DOI：
10.1073/pnas.2234055100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Altan-Bonnet, N;Phair, RD;Lippincott-Schwartz, J
通讯作者：
Lippincott-Schwartz, J
影响因子：
3.5
作者：
Duan, Haichuan;Jefcoate, Colin R.
通讯作者：
Jefcoate, Colin R.
DOI：
10.1016/s1357-2725(01)00049-8
发表时间：
2001-08-01
影响因子：
4
作者：
Abo-Hashema, KAH;Cake, MH;Knudsen, J
通讯作者：
Knudsen, J
影响因子：
56.9
作者：
ALHO, H;COSTA, E;GUIDOTTI, A
通讯作者：
GUIDOTTI, A