Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1.
Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1.
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感染了Inaba或Ogawa血清型的脱水腹泻患者的临床特征和免疫学参数的比较。
DOI：
10.3109/00365540903289688
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发表时间：
2010
影响因子：
--
通讯作者：
Qadri F
中科院分区：
文献类型：
--
作者：
Khan AI;Chowdhury F;Harris JB;Larocque RC;Faruque AS;Ryan ET;Calderwood SB;Qadri F
O1型霍乱弧菌，小川型和稻叶型，都能引起严重的霍乱。我们比较了孟加拉国感染这两种血清型患者的临床和免疫学特征。在急性期（第2天）、第5天和第19天分别对住院的小川（N = 146）或稻叶（N = 191）患者采集血液。小川患者比稻叶患者年龄小，腹泻持续时间短，腹痛、呕吐和静脉输液更频繁（p < 0.05）。稻叶患者多见暗野阳性便（p < 0.01）。稻叶菌株对四环素和红霉素的敏感性高于小川菌株（p < 0.001）。小川感染对霍乱毒素B亚基、毒素协同调节菌毛亚基和脂多糖（LPS）产生更高的血浆杀弧菌和IgG反应；“淋巴细胞上清抗体”（ALS）标本中IgA对LPS的反应也较高。这些结果表明，基于Ogawa血清型的霍乱疫苗需要进一步研究。
Vibrio cholerae O1, Ogawa and Inaba serotypes, both cause severe cholera. We compared clinical and immunological features in patients in Bangladesh infected with these 2 serotypes. Blood was collected from hospitalized Ogawa (N = 146) or Inaba (N = 191) patients at the acute stage (day 2) and 5 and 19 days later. Ogawa patients were younger than Inaba, presented with shorter duration of diarrhoea, and had more frequent abdominal pain, vomiting and need for intravenous fluids (p < 0.05). Inaba patients more frequently had dark-field positive stools (p < 0.01). Inaba strains were more susceptible to tetracycline and erythromycin than Ogawa strains (p < 0.001). Ogawa infection produced higher plasma vibriocidal as well as IgG responses to cholera toxin B subunit, toxin-coregulated pilus subunit and lipopolysaccharide (LPS); higher IgA responses to LPS in ‘antibody in lymphocyte supernatant’ (ALS) specimens were also seen. These results suggest that a cholera vaccine based on the Ogawa serotype needs to be further investigated.
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影响因子：
2.8
作者：
Begum, Y. A.;Talukder, K. A.;Qadri, F.
通讯作者：
Qadri, F.
影响因子：
3.1
作者：
Qadri, F;Ryan, ET;Calderwood, SB
通讯作者：
Calderwood, SB
影响因子：
6.4
作者：
LEVINE, MM;BLACK, RE;YOUNG, CR
通讯作者：
YOUNG, CR
影响因子：
--
作者：
Faruque, ASG;Malek, MA;Sack, DA
通讯作者：
Sack, DA
DOI：
10.1097/inf.0b013e3181783adf
发表时间：
2008-11
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Chowdhury F;Khan AI;Harris JB;LaRocque RC;Chowdhury MI;Ryan ET;Faruque AS;Calderwood SB;Qadri F
通讯作者：
Qadri F