Acellular nerve allografts in peripheral nerve regeneration: a comparative study.
Acellular nerve allografts in peripheral nerve regeneration: a comparative study.
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DOI：
10.1002/mus.22033
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发表时间：
2011-08
期刊：
影响因子：
3.4
通讯作者：
Johnson, Philip J.
中科院分区：
文献类型：
--
作者：
Moore, Amy M.;MacEwan, Matthew;Santosa, Katherine B.;Chenard, Kristofer E.;Ray, Wilson Z.;Hunter, Daniel A.;Mackinnon, Susan E.;Johnson, Philip J.
关键词：
Processed nerve allografts offer a promising alternative to nerve autografts in the surgical management of peripheral nerve injuries where short deficits exist. Three established models of acellular nerve allograft (cold-preserved, detergent-processed, and AxoGen® -processed nerve allografts) were compared to nerve isografts and silicone nerve guidance conduits in a 14 mm rat sciatic nerve defect. All acellular nerve grafts were superior to silicone nerve conduits in support of nerve regeneration. Detergent-processed allografts were similar to isografts at 6 weeks post-operatively, while AxoGen®-processed and cold-preserved allografts supported significantly fewer regenerating nerve fibers. Measurement of muscle force confirmed that detergent-processed allografts promoted isograft-equivalent levels of motor recovery 16 weeks post-operatively. All acellular allografts promoted greater amounts of motor recovery compared to silicone conduits. These findings provide evidence that differential processing for removal of cellular constituents in preparing acellular nerve allografts affects recovery in vivo.
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影响因子：
--
作者：
Hodde, JP;Record, RD;Badylak, SF
通讯作者：
Badylak, SF
影响因子：
5.3
作者：
Graham, James B.;Neubauer, Debbie;Muir, David
通讯作者：
Muir, David
影响因子：
14
作者：
Hodde, J;Record, R;Badylak, S
通讯作者：
Badylak, S
影响因子：
2.9
作者：
DANIELSEN, N;KERNS, JM;KANJE, M
通讯作者：
KANJE, M
影响因子：
6.2
作者：
HARE, GMT;EVANS, PJ;HAY, JB
通讯作者：
HAY, JB