Serum 5-Hydroxytryptamine is Related to Psoriasis Severity in Patients with Comorbid Anxiety or Depression.

Serum 5-Hydroxytryptamine is Related to Psoriasis Severity in Patients with Comorbid Anxiety or Depression.
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血清 5-羟色胺与共病焦虑或抑郁患者的银屑病严重程度相关

DOI:
10.2340/00015555-3857
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发表时间:
2021-08-16
影响因子:
3.6
通讯作者:
Zhu, Wu
Zhu, Wu
中科院分区:
医学3区
文献类型:
--
作者:
Shen, Minxue;Cao, Duling;Xiao, Yi;Kuang, Yehong;Jing, Danrong;LI, Yaji;Liu, Panpan;Chen, Xiang;Zhu, Wu

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表明肠通透性可能独立于中枢神经系统调节5-HT的分泌,但与5-HT一样,当精神共病不存在时,它可能不影响银屑病。建立中介效应模型,发现5-HT对焦虑、抑郁患者的LPS与PASI的相关性有显著中介作用(β = 8.82,p = 0.022)。
indicates that intestinal permeability may regulate the secretion of 5-HT independent from the CNS, but, like 5-HT, it may not affect psoriasis when mental comorbidity was not present. A mediation effect model was then established and it was found that 5-HT significantly mediated (β = 8.82, p = 0.022) the correlation between LPS and PASI in patients with anxiety or depression.
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