Phase resetting in duper hamsters: specificity to photic zeitgebers and circadian phase.
Phase resetting in duper hamsters: specificity to photic zeitgebers and circadian phase.
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DOI：
10.1177/0748730414568297
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发表时间：
2015-04
影响因子：
3.5
通讯作者：
Bittman EL
中科院分区：
文献类型：
--
作者：
Manoogian EN;Leise TL;Bittman EL
叙利亚仓鼠中的duper突变将自发活动的自由运行期（τDD）缩短至约23 h，并导致对15 min光脉冲的0型相位响应曲线（PRC）。为了确定夸张的相移是否是特定的光线索和/或限制主观的夜晚，我们进行了仓鼠在主观的白天新颖的车轮限制和黑暗的脉冲。小相移引起的nonphotic线索是可比的突变体和野生型（WT）仓鼠，但黑暗的脉冲触发更大的变化骗子。为了进一步评估duper突变对光暗转换的影响，我们在不同的昼夜节律阶段将仓鼠在恒定光照（LL）和恒定黑暗（DD）之间或DD和LL之间转移。Duper仓鼠表现出显着较大的相移比WT仓鼠时，从LL到DD在主观的白天和从DD到LL在主观的夜晚。在所有时间点，duper仓鼠对所有亮/暗转换的响应相移的变异性显著更大。此外，大多数duper仓鼠，但没有WT，显示短暂的ultradian轮运行模式5至12天时，从光明转移到黑暗中的CT 18。χ2周期图和自相关分析表明，这些ultradian模式不同于SCN病变或暴露于恒定强光下的节律性破坏。我们的结论是，duper突变专门放大相移光的线索，并可能不稳定耦合的昼夜节律组织光的挑战，由于昼夜节律起搏器的组件之间的耦合减弱。昼夜节律起搏器的数学模型支持这一假设。
The duper mutation in Syrian hamsters shortens the free-running period of locomotor activity (τDD) to about 23 h and results in a type 0 phase-response curve (PRC) to 15-min light pulses. To determine whether exaggerated phase shifts are specific to photic cues and/or restricted to subjective night, we subjected hamsters to novel wheel confinements and dark pulses during subjective day. Small phase shifts elicited by the nonphotic cue were comparable in mutant and wild-type (WT) hamsters, but dark pulses triggered larger shifts in dupers. To assess further the effects of the duper mutation on light-dark transitions, we transferred hamsters between constant light (LL) and constant dark (DD) or between DD and LL at various circadian phases. Duper hamsters displayed significantly larger phase shifts than WT hamsters when transferred from LL to DD during subjective day and from DD to LL during subjective night. The variability of phase shifts in response to all light/dark transitions was significantly greater in duper hamsters at all time points. In addition, most duper hamsters, but none of the WTs, displayed transient ultradian wheel-running patterns for 5 to 12 days when transferred from light to dark at CT 18. The χ2 periodogram and autocorrelation analyses indicate that these ultradian patterns differ from the disruption of rhythmicity by SCN lesions or exposure to constant bright light. We conclude that the duper mutation specifically amplifies phase shifts to photic cues and may destabilize coupling of circadian organization upon photic challenge due to weakened coupling among components of the circadian pacemaker. Mathematical modeling of the circadian pacemaker supports this hypothesis.
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影响因子：
3.7
作者：
Bittman EL
通讯作者：
Bittman EL
影响因子：
16.2
作者：
Freeman GM Jr;Krock RM;Aton SJ;Thaben P;Herzog ED
通讯作者：
Herzog ED
影响因子：
3.4
作者：
Gonze, D;Bernard, S;Herzel, H
通讯作者：
Herzel, H
DOI：
10.1073/pnas.96.26.15211
发表时间：
1999-12-21
影响因子：
11.1
作者：
Maywood, ES;Mrosovsky, N;Hastings, MH
通讯作者：
Hastings, MH
DOI：
10.1007/bf00609437
发表时间：
1982-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
BOULOS, Z;RUSAK, B
通讯作者：
RUSAK, B