Cold Blooded: Evaluating Brain Temperature by MRI During Surface Cooling of Human Subjects.
Cold Blooded: Evaluating Brain Temperature by MRI During Surface Cooling of Human Subjects.
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DOI：
10.1007/s12028-017-0389-4
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发表时间：
2017-10
影响因子：
3.5
通讯作者：
Freeman K
中科院分区：
文献类型：
--
作者：
Curran EJ;Wolfson DL;Watts R;Freeman K
靶向体温管理（TTM）为心脏骤停后自主循环（ROSC）恢复但仍处于昏迷状态的患者提供神经和生存益处。在院前环境中没有用于诱导低温的专门设备，并且没有可靠的方法供紧急医疗服务人员启动TTM。我们假设在颈部应用表面冷却元件将降低脑温度并作为TTM的引发剂。磁共振（MR）波谱被用来评估颈动脉表面冷却元件对健康成人脑温度的影响。六个人完成了这项研究。在应用冷却元件后，我们测量到大脑皮层中的温度下降为0.69 ± 0.38 °C（95%CI）。室温元件的应用还导致脑温度可测量的降低0.66 ± 0.41 °C（95%CI），这可能归因于压力感受器激活。将表面冷却元件应用于颈部降低了脑温，可以作为在院前环境中启动TTM的方法。
Targeted temperature management (TTM) confers neurological and survival benefits for post-cardiac arrest patients with return of spontaneous circulation (ROSC) who remain comatose. Specialized equipment for induction of hypothermia is not available in the prehospital setting, and there are no reliable methods for emergency medical services personnel to initiate TTM. We hypothesized that the application of surface cooling elements to the neck will decrease brain temperature and act as initiators of TTM. Magnetic resonance (MR) spectroscopy was used to evaluate the effect of a carotid surface cooling element on brain temperature in healthy adults. Six individuals completed this study. We measured a temperature drop of 0.69 ± 0.38 °C (95% CI) in the cortex of the brain following the application of the cooling element. Application of a room temperature element also caused a measurable decrease in brain temperature of 0.66 ± 0.41 °C (95% CI) which may be attributable to baroreceptor activation. The application of surface cooling elements to the neck decreased brain temperature and may serve as a method to initiate TTM in the prehospital setting.
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影响因子：
158.5
作者：
Nielsen, Niklas;Wettersley, Jorn;Friberg, Hans
通讯作者：
Friberg, Hans
影响因子：
3.5
作者：
Matsui, Tomohiro;Yoshida, Yusuke;Suenaga, Hiromi
通讯作者：
Suenaga, Hiromi
影响因子：
3.5
作者：
Mink, Susanne;Schwarz, Urs;Keller, Emanuela
通讯作者：
Keller, Emanuela
影响因子：
158.5
作者：
Bernard, SA;Gray, TW;Smith, K
通讯作者：
Smith, K
DOI：
10.2170/jjphysiol.53.461
发表时间：
2003-12-01
期刊：
JAPANESE JOURNAL OF PHYSIOLOGY
影响因子：
--
作者：
Zhang, DM;Ando, M;Sato, T
通讯作者：
Sato, T