Impact evaluation of the routine hepatitis B vaccination program of infants in China.
Impact evaluation of the routine hepatitis B vaccination program of infants in China.
复制标题
DOI：
10.1093/pubmed/fdy015
复制
发表时间：
2019-03-01
期刊：
影响因子：
--
通讯作者：
Hao M
中科院分区：
文献类型：
--
作者：
Sun M;Li C;Li P;Lu J;Wang Y;Chang F;Li X;Hao M
目的：评价中国婴幼儿常规乙肝疫苗接种计划的效果。2004 - 2010年期间，乙型肝炎新发感染率和按年龄组和省份分列的三剂疫苗覆盖率数据来自全国传染病网络直接报告系统。采用卡方检验和Pearson相关分析，分析不同省份疫苗接种率的发病率差异及三剂接种率与发病率的关系。全覆盖儿童（0 ~ 15岁）新发感染率为8.96/10万，显著低于部分覆盖和无覆盖儿童。2010年0 ~ 9岁儿童新发感染率为6.36/10万，与2004年相比有显著下降。考虑到疫苗接种对0 - 5岁儿童累计发病率的影响，在疫苗接种率最低至最高的省份，新发感染率高出2.2倍。随着时间的推移，中国婴儿常规乙肝疫苗接种计划的影响越来越明显。在扩大规划的同时，要注意规划实施和区域不平衡。
To evaluate the impact of the routine hepatitis B vaccination program of infants in China. The incidence of new hepatitis B infection and coverage with three doses of the vaccines by age groups and provinces were derived from the National Network Direct Report System of Infectious Disease during 2004–10. Chi square test and Pearson correlation analysis were used to analyze differences in incidence according to vaccination coverage and the relationship between the coverage with three doses and the incidence in different provinces. The incidence of new infection was 8.96/100 000 among children with complete coverage (0–15 years old), which was significantly lower than that with partial or no coverage. Among 0–9-year-old children in 2010, the incidence of new infection was 6.36/100 000, which was significantly lower than 2004. Considering the impact of vaccination on cumulative incidence among 0–5-year-old children, a 2.2-fold greater incidence of new infection was observed in provinces with the lowest to the highest vaccination rate. The impact of the routine hepatitis B vaccination program of infants in China has become more apparent over time. Program implementation and regional disequilibrium should be payed attention to as well as the expanded program.
登录
查看更多内容
影响因子：
6.4
作者：
Liang, Xiaofeng;Bi, Shengli;Wang, Yu
通讯作者：
Wang, Yu
影响因子：
5.9
作者：
LITTENBERG, B;RANSOHOFF, DF
通讯作者：
RANSOHOFF, DF
影响因子：
5.4
作者：
Ng, KP;Saw, TL;Ramanathan, M
通讯作者：
Ramanathan, M
初次血浆源性乙型肝炎疫苗接种 23 年后的抗体水平和免疫记忆：来自流行率较高的中国的随机安慰剂对照试验队列的结果
影响因子：
5.5
作者：
Wu, Qian;Zhuang, Gui-Hua;Zhang, Min
通讯作者：
Zhang, Min
影响因子：
6.1
作者：
Lu Feng-min;Zhuang Hui
通讯作者：
Zhuang Hui