Sleep problems associated with behavioral and psychological symptoms as well as cognitive functions in Alzheimer's disease.
Sleep problems associated with behavioral and psychological symptoms as well as cognitive functions in Alzheimer's disease.
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DOI：
10.3988/jcn.2014.10.3.203
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Park KH
中科院分区：
文献类型：
--
作者：
Shin HY;Han HJ;Shin DJ;Park HM;Lee YB;Park KH
研究表明，阿尔茨海默病（AD）的睡眠问题与认知障碍和行为问题有关。事实上，大多数研究已经发现白天嗜睡与AD的认知功能下降显著相关。然而，一些研究也表明，夜间睡眠问题与AD的认知功能和行为症状有关。因此，本研究的目的是评估夜间睡眠对AD患者的认知和行为及精神痴呆症状（BPSD）的影响。研究人群包括117例受试者：63例AD患者和54例年龄和性别匹配的非痴呆老年受试者。使用首尔神经心理筛选成套测验（SNSB）和韩国版神经精神量表（NPI-K）测量详细的认知功能和行为症状。使用韩国版匹兹堡睡眠质量指数（PSQI-K）评估睡眠特征。分析PSQI-K与SNSB评分、PSQI-K与NPI-K评分的相关性。在AD患者中，睡眠潜伏期与praxis（p=0.041）、Rey-Osterrieth复杂图形测试（RCFT）即时回忆（p=0.041）和RCFT识别（p=0.008）呈负相关，而睡眠持续时间和睡眠效率与praxis呈正相关（分别为p=0.034和p=0.025）。虽然PSQI-K和NPI-K评分之间没有显著相关性，但睡眠障碍和PSQI-K总评分与AD的冷漠/冷漠显著相关。AD患者的睡眠问题，如睡眠时间延长、睡眠潜伏期和睡眠效率低下与认知功能障碍相关，尤其是额叶执行功能和视觉空间功能以及BPSD。这些发现表明，治疗夜间睡眠问题可能会改善AD患者的认知和行为症状。
It has been shown that sleep problems in Alzheimer's disease (AD) are associated with cognitive impairment and behavioral problems. In fact, most of studies have founded that daytime sleepiness is significantly correlated with cognitive decline in AD. However, a few studies have also shown that nighttime sleep problems are associated with cognitive function and behavioral symptoms in AD. Accordingly, the aim of this study was to evaluate the effects of nighttime sleep on cognition and behavioral and psychological symptoms of dementia (BPSD) in AD. The study population comprised 117 subjects: 63 AD patients and 54 age- and sex-matched non-demented elderly subjects. Detailed cognitive functions and behavioral symptoms were measured using the Seoul Neuropsychological Screening Battery (SNSB) and the Korean version of the Neuropsychiatric Inventory (NPI-K). Sleep characteristics were evaluated using the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K). The correlations between PSQI-K and SNSB scores and between PSQI-K and NPI-K scores were analyzed. In AD patients, sleep latency was found to be negatively correlated with praxis (p=0.041), Rey-Osterrieth Complex Figure Test (RCFT) immediate recall (p=0.041), and RCFT recognition (p=0.008) after controlling for age and education, while sleep duration and sleep efficiency were positively correlated with praxis (p=0.034 and p=0.025, respectively). Although no significant correlation was found between PSQI-K and NPI-K scores, sleep disturbance and total PSQI-K scores were found to be significantly associated with apathy/indifference in AD. Sleep problems such as prolonged sleep duration, sleep latency, and poor sleep efficiency in AD patients were correlated with cognitive dysfunction, and especially frontal executive and visuospatial functions, and BPSD. These findings suggest that treatment of nighttime sleep problems might improve cognition and behavioral symptoms in AD patients.
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影响因子：
4.8
作者：
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通讯作者：
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作者：
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通讯作者：
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