Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults.
Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults.
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DOI：
10.1192/j.eurpsy.2022.23
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发表时间：
2022-06-13
影响因子：
7.8
通讯作者：
Hickie, Ian B.
中科院分区：
文献类型：
--
作者：
Crouse, Jacob J.;Ho, Nicholas;Scott, Jan;Parker, Richard;Park, Shin Ho;Couvy-Duchesne, Baptiste;Mitchell, Brittany L.;Byrne, Enda M.;Hermens, Daniel F.;Medland, Sarah E.;Martin, Nicholas G.;Gillespie, Nathan A.;Hickie, Ian B.
阈下/减弱综合征是全阈情绪和精神病性障碍的既定前兆。关于阈下综合征发展之前的个体症状以及新兴成人中相关的社会/功能结果知之甚少。我们建立了两个动态贝叶斯网络（DBN），以调查在布里斯班纵向双胞胎研究的19 Up和25 Up波中自评现象学和个人/生活方式因素（角色障碍，低社会支持，酒精和物质使用）之间的关联。我们检查了19岁以上的症状和个人/生活方式因素是否与（a）25岁以上的自身或不同项目相关，以及（B）25岁以上的抑郁样、亚躁狂样或精神病样阈下综合征（STS）发作相关。第一个DBN确定了11个项目，当在19 Up背书时，更有可能在25 Up重新背书（例如，睡眠过度、注意力不集中、睡眠质量不佳）和当在19 Up被认可时与在25 Up被认可的不同项目相关联的七个项目（例如，早期疲劳和后期角色受损;早期运动能力丧失和后期躯体疼痛）。在第二个DBN中，没有弧满足我们的先验阈值。在一个没有阈值的探索性模型中，19岁以上的20个项目与25岁以上的STS进展相关（具有较低的统计学置信度）;前五个弧是：感觉受到他人的威胁和后来的精神病样STS;活动增加和后来的低躁狂样STS;以及运动障碍，睡眠质量受损和/或嗜睡和后来的抑郁样STS。这些概率模型识别症状和个人/生活方式因素，可能证明有用的目标，为指示的预防策略。
Subthreshold/attenuated syndromes are established precursors of full-threshold mood and psychotic disorders. Less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social/functional outcomes among emerging adults. We modeled two dynamic Bayesian networks (DBN) to investigate associations among self-rated phenomenology and personal/lifestyle factors (role impairment, low social support, and alcohol and substance use) across the 19Up and 25Up waves of the Brisbane Longitudinal Twin Study. We examined whether symptoms and personal/lifestyle factors at 19Up were associated with (a) themselves or different items at 25Up, and (b) onset of a depression-like, hypo-manic-like, or psychotic-like subthreshold syndrome (STS) at 25Up. The first DBN identified 11 items that when endorsed at 19Up were more likely to be reendorsed at 25Up (e.g., hypersomnia, impaired concentration, impaired sleep quality) and seven items that when endorsed at 19Up were associated with different items being endorsed at 25Up (e.g., earlier fatigue and later role impairment; earlier anergia and later somatic pain). In the second DBN, no arcs met our a priori threshold for inclusion. In an exploratory model with no threshold, >20 items at 19Up were associated with progression to an STS at 25Up (with lower statistical confidence); the top five arcs were: feeling threatened by others and a later psychotic-like STS; increased activity and a later hypo-manic-like STS; and anergia, impaired sleep quality, and/or hypersomnia and a later depression-like STS. These probabilistic models identify symptoms and personal/lifestyle factors that might prove useful targets for indicated preventative strategies.
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影响因子：
5.7
作者：
Li, Junning;Wang, Z. Jane;McKeown, Martin J.
通讯作者：
McKeown, Martin J.
影响因子：
6.8
作者：
Crouse JJ;Ho N;Scott J;Martin NG;Couvy-Duchesne B;Hermens DF;Parker R;Gillespie NA;Medland SE;Hickie IB
通讯作者：
Hickie IB
影响因子：
5
作者：
McNally RJ;Heeren A;Robinaugh DJ
通讯作者：
Robinaugh DJ
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
6.7
作者：
Konings, M.;Bak, M.;Krabbendam, L.
通讯作者：
Krabbendam, L.