Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia
Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia
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褪黑激素丰富的形觉剥夺性近视小鼠模型中视网膜多巴胺水平的改变
DOI：
10.1007/s12264-022-00842-9
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Shi-Jun Weng
中科院分区：
文献类型：
--
作者：
Kang-Wei Qian;Yun-Yun Li;Xiao-Hua Wu;Xue Gong;Ai-Lin Liu;Wen-Hao Chen;Zhe Yang;Ling-Jie Cui;Yun-Feng Liu;Yuan-Yuan Ma;Chen-Xi Yu;Furong Huang;Qiongsi Wang;Xiangtian Zhou;Jia Qu;Yong-Mei Zhong;Xiong-Li Yang;Shi-Jun Weng
视网膜多巴胺（眼睛发育的关键调节因子）水平的降低与许多物种的实验性近视有关，但在缺乏褪黑激素（一种与多巴胺广泛相互作用的神经激素）的C57BL/6小鼠的近视眼睛中未见。在这里，我们研究了褪黑激素熟练的CBA/CaJ小鼠的形式剥夺性近视（FDM）和视网膜多巴胺水平之间的关系。我们发现，这些小鼠在缺乏形状的眼睛中表现出近视的屈光位移，这伴随着视网膜多巴胺水平的改变。当药物阻断褪黑激素受体时，FDM仍然可以诱导，但其程度降低，FDM动物的视网膜多巴胺水平不再改变，表明褪黑激素相关的视网膜多巴胺水平变化有助于FDM的发生。因此，在CBA/CaJ小鼠中，FDM是由多巴胺水平独立和褪黑激素相关的多巴胺水平依赖机制介导的。先前报道的近视C57BL/6小鼠视网膜多巴胺水平不变可能归因于褪黑激素缺乏。
Reduced levels of retinal dopamine, a key regulator of eye development, are associated with experimental myopia in various species, but are not seen in the myopic eyes of C57BL/6 mice, which are deficient in melatonin, a neurohormone having extensive interactions with dopamine. Here, we examined the relationship between form-deprivation myopia (FDM) and retinal dopamine levels in melatonin-proficient CBA/CaJ mice. We found that these mice exhibited a myopic refractive shift in form-deprived eyes, which was accompanied by altered retinal dopamine levels. When melatonin receptors were pharmacologically blocked, FDM could still be induced, but its magnitude was reduced, and retinal dopamine levels were no longer altered in FDM animals, indicating that melatonin-related changes in retinal dopamine levels contribute to FDM. Thus, FDM is mediated by both dopamine level-independent and melatonin-related dopamine level-dependent mechanisms in CBA/CaJ mice. The previously reported unaltered retinal dopamine levels in myopic C57BL/6 mice may be attributed to melatonin deficiency.
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DOI：
10.1016/s0165-3806(01)00103-1
发表时间：
2001-03
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
A. Simon;E. Martin‐Martinelli;C. Savy;C. Verney;R. Raisman‐Vozari;J. Nguyen‐Legros
通讯作者：
A. Simon;E. Martin‐Martinelli;C. Savy;C. Verney;R. Raisman‐Vozari;J. Nguyen‐Legros
影响因子：
2.9
作者：
S. Ebihara;D. Hudson;T. Marks;M. Menaker
通讯作者：
S. Ebihara;D. Hudson;T. Marks;M. Menaker
影响因子：
16.2
作者：
Esposti F;Johnston J;Rosa JM;Leung KM;Lagnado L
通讯作者：
Lagnado L
影响因子：
1.9
作者：
Fujieda, H;Scher, J;Brown, GM
通讯作者：
Brown, GM
影响因子：
4.4
作者：
M. J. Gastinger;J. O’Brien;N. B. Larsen;D. Marshak
通讯作者：
M. J. Gastinger;J. O’Brien;N. B. Larsen;D. Marshak