Progression of atherosclerosis in hemodialysis patients: effect of adiponectin on carotid intima media thickness.
Progression of atherosclerosis in hemodialysis patients: effect of adiponectin on carotid intima media thickness.
复制标题
血液透析患者动脉粥样硬化的进展：脂联素对颈动脉内膜中层厚度的影响。
DOI：
10.5551/jat.e548
复制
发表时间：
2008
影响因子：
4.4
通讯作者：
C. Ohyama
中科院分区：
文献类型：
--
作者：
M. Tsushima;Y. Terayama;A. Momose;T. Funyu;C. Ohyama
目标
我们研究了与血液透析(HD)患者颈总动脉内膜中层厚度(IMT)进展相关的参数。
方法
85例患者在基线和12个月后进行超声检查。计算两个时间点的IMT差值(DeltaIMT)。我们将DeltaIMT<；or=0.00定义为“进展”，将DeltaIMT0.00定义为“稳定”。在CT上计算体脂分布。采用双抗体夹心法测定血清总脂联素(T-Ad)和高分子脂联素(H-Ad)水平。
结果
除基线时H-Ad与T-Ad的比值(HMWR)外，两组间所有指标均无显著差异。进展组IMT由1.56±0.89增至1.77±0.94 mm(p<；0.001)，内脏脂肪面积增加(60.3±30.7至69.2±37.5cm2；p<；0.01)。在“稳定”组，HMWR从31.3%+/-5.4%增加到37.6%+/-7.3%(p<；0.001)。多元Logistic回归分析选择了DeltaHMWR(p=0.031，优势比=0.928)，与IMT的进展无关。DeltaIMT与DeltaHMWR的相关系数为-0.254(p=0.019)。
结论
我们发现HD患者HMWR的增加与IMT的稳定状态有关。
AIM
We investigated the parameters related to the progression of common carotid artery intima media thickness (IMT) in hemodialysis (HD) patients.
METHODS
IMT was examined in 85 patients by ultrasonography at baseline and after 12 months. The difference in IMT between these two time points was calculated (DeltaIMT). We defined DeltaIMT< or =0.00 as 'progression', and DeltaIMT0.00 as 'stable'. Body fat distribution was calculated on computed tomography. Total adiponectin (T-Ad) and high molecular weight adiponectin (H-Ad) were measured by ELISA.
RESULTS
There were no significant differences between the two groups in all profiles except for the ratio of H-Ad to T-Ad (HMWR) at baseline. In the 'progression' group, IMT increased from 1.56+/-0.89 to 1.77+/-0.94 mm (p<0.001) and visceral fat area (60.3+/-30.7 to 69.2+/-37.5, cm2; p<0.01) increased. In the 'stable' group, HMWR increased from 31.3+/-5.4 to 37.6+/-7.3% (p<0.001). Multiple logistic regression analysis selected DeltaHMWR (p=0.031, odds ratio=0.928) independently of IMT progression. The correlation coefficient was -0.254 (p=0.019) between DeltaIMT and DeltaHMWR.
CONCLUSIONS
We found that an increase in HMWR was related to the stable state of IMT in HD patients.
影响因子：
8.3
作者：
OLeary, DH;Polak, JF;Furberg, CD
通讯作者：
Furberg, CD
影响因子：
158.5
作者：
Ridker, PM;Cushman, M;Hennekens, CH
通讯作者：
Hennekens, CH