Surgical findings in cryptorchidism in children with Zika-related microcephaly: a case series.
Surgical findings in cryptorchidism in children with Zika-related microcephaly: a case series.
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DOI：
10.1186/s12894-020-00721-3
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发表时间：
2020-11-23
期刊：
影响因子：
2
通讯作者：
Miranda-Filho DB
中科院分区：
文献类型：
--
作者：
de Vasconcelos RAL;Ximenes RAA;Calado AA;Martelli CMT;Gonçalves AV;Brickley EB;de Araújo TVB;Rocha MAW;Miranda-Filho DB
寨卡综合征的病因有哪些？巴西伯南布哥的小头症流行病研究小组/MERG报告了一种并发症，即隐睾症。本文首次描述了患有寨卡相关小头畸形和隐睾症的男孩病例系列的手术结果，这些男孩接受了手术睾丸探查，以更好地了解性腺形成和下降的可能机制。2019年8月至2020年1月期间，共有7名3至4岁的儿童（11个睾丸单位）接受腹股沟或阴囊睾丸固定术治疗可触及隐睾症。描述了性腺及其附件与阑尾、睾丸-附睾分离、引带附着以及相关鞘膜积液和/或疝的特征。以厘米为单位进行体积计算。我们发现睾丸和附睾阑尾的患病率较低（66.7%），睾丸-附睾分离的患病率较高（55.6%），平均睾丸体积较低（年龄较大的男孩较低），所有病例中异位引带插入。任何病例均无相关鞘膜积液和/或疝的证据。没有登记或报告手术并发症，所有探查的性腺均正确放置在阴囊内。我们在此描述了这些儿童的睾丸固定术的手术结果，并讨论了胚胎发生和出生后睾丸和附件的生长和发育中病毒作用的可能机制。由于睾丸萎缩和恶性肿瘤的风险较高，这些儿童需要长期随访。手术时机似乎与避免睾丸体积损失有关。
Complications in the urinary tract related to congenital Zika syndrome have recently been reported. One complication, cryptorchidism, has been reported by the Microcephaly Epidemic Research Group/MERG, in Pernambuco/Brazil. The present article describes for the first time the surgical findings in a case series of boys with Zika-related microcephaly and cryptorchidism, who underwent surgical testicular exploration as a contribution to better understand the possible mechanisms involved in gonads formation and descent. A total of 7 children (11 testicular units), aged 3 to 4 years, were submitted to inguinal or scrotal orchidopexy for the treatment of palpable cryptorchidism between August 2019 and January 2020. Characteristics of the gonads and its annexes related to appendixes, testis-epididymis dissociation, gubernacular insertion, and associated hydroceles and/or hernias were described. Measures in centimetres were taken for volume calculate. We found a low prevalence of testicular and epididymal appendix (66.7%), a high prevalence of testis-epididymis dissociation (55.6%), low mean testicular volume for their ages (lower for older boys) and ectopic gubernacular insertion in all cases. There was no evidence of associated hydroceles and/or hernias in any case. No surgical complication was registered or reported, and all explored gonads were properly placed in the scrotal sac. We herein describe the surgical findings of these children's orchidopexies and discuss the possible mechanisms of viral action in embryogenesis and postnatal growth and development of the testes and annexes. These children need to be followed over time due to the higher risk of testicular atrophy and malignancy. Surgical timing seems to be relevant to avoid loss of testicular volume.
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影响因子：
3.3
作者：
de Vasconcelos, Romulo A. L.;Ximenes, Ricardo A. A.;Miranda-Filho, Democrito de B.
通讯作者：
Miranda-Filho, Democrito de B.
影响因子：
168.9
作者：
Franca, Giovanny V. A.;Schuler-Faccini, Lavinia;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
DOI：
10.1038/nrurol.2017.90
发表时间：
2017-09
期刊：
Nature reviews. Urology
影响因子：
--
作者：
Gurney JK;McGlynn KA;Stanley J;Merriman T;Signal V;Shaw C;Edwards R;Richiardi L;Hutson J;Sarfati D
通讯作者：
Sarfati D
影响因子：
2.4
作者：
Vries, Annebeth Meij-de;Hack, Wilfried W. M.;Meijer, Robert W.
通讯作者：
Meijer, Robert W.
影响因子：
29
作者：
de Oliveira Melo, Adriana Suely;Aguiar, Renato Santana;Tanuri, Amilcar
通讯作者：
Tanuri, Amilcar