High birth weight and risk of specific childhood cancers: a report from the Children's Cancer Group.
High birth weight and risk of specific childhood cancers: a report from the Children's Cancer Group.
复制标题
高出生体重和特定儿童癌症的风险：儿童癌症小组的报告。
DOI：
10.1016/s0022-3476(97)70091-x
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Robison,LL
中科院分区：
文献类型：
--
作者：
Yeazel,MW;Ross,JA;Buckley,JD;Woods,WG;Ruccione,K;Robison,LL
ObjectivesHigh birth weight has been associated with a number of childhood cancers. This study was conducted to test the hypothesis that elevated birth weight is associated with an increased risk of diagnosis-specific and age-specific groups of childhood cancers.MethodsA case-control study, using a large Children’s Cancer Group database, examined birth weight as a risk factor for childhood cancer. Birth weight information for the index child was available for 3711 cases and 816 control subjects.ResultsThere was a statistically significant increased risk of acute lymphoblastic leukemia, Wilms’ tumor, and neuroblastoma with increasing birth weight ( p, trend = 0.006, 0.003, and 0.001, respectively). A statistically significant decreased risk of cancer was observed for soft tissue sarcoma ( p, trend = 0.04). When data were stratified on the basis of age at diagnosis, many of these associations were apparent for children whose disease was diagnosed before the age of 2 years. Moreover, for acute myeloid leukemia, age at diagnosis was an important effect modifier. For children with acute myeloid leukemia whose disease was diagnosed before 2 years of age, there was a statistically significant increased risk with high birth weight (odds ratio = 2.5, 95% confidence interval 1.1 to 5.5); there was no increased risk of acute myeloid leukemia with high birth weight noted for children whose disease was diagnosed after 2 years of age (odds ratio 1.3, 95% confidence interval 0.8 to 2.2).ConclusionsBiologic studies are needed to address why high birth weight may increase risk (particularly at younger ages) of development of certain cancers. (J Pediatr 1997;131:671-7)
登录
查看更多内容
肾母细胞瘤的危险因素：国家肾母细胞瘤研究报告
影响因子：
6.2
作者：
A. Olshan;N. Breslow;J. Falletta;S. Grufferman;Thomas M. Pendergrass;L. Robison;M. Waskerwitz;W. Woods;T. Vietti;G. Hammond
通讯作者：
G. Hammond
幼儿星形细胞胶质瘤和原始神经外胚层肿瘤的危险因素：儿童癌症小组的报告。
DOI：
--
发表时间：
1994
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Bunin,GR;Buckley,JD;Boesel,CP;Rorke,LB;Meadows,AT
通讯作者：
Meadows,AT
新南威尔士州儿童恶性脑瘤的围产期和产后早期危险因素
影响因子：
6.4
作者：
M. Mccredie;P. Maisonneuve;P. Boyle
通讯作者：
P. Boyle
影响因子：
1.1
作者：
BIRCH J M;HARTLEY A L;ET AL
通讯作者：
ET AL
影响因子：
5
作者：
SHAW, G;LAVEY, R;AUSTIN, D
通讯作者：
AUSTIN, D