Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.
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DOI：
10.3390/molecules20010185
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发表时间：
2014-12-24
期刊：
影响因子：
--
通讯作者：
Prasad S
中科院分区：
文献类型：
--
作者：
Aggarwal BB;Deb L;Prasad S
姜黄素（二阿魏酰甲烷），一种来自姜黄的金色色素，具有抗氧化、抗炎、抗癌、抗病毒、抗菌和抗糖尿病的特性。这些活性中的大部分已被分配给姜黄素中存在的甲氧基、羟基、α，β-不饱和羰基部分或二酮基团。姜黄素的主要代谢产物之一是四氢姜黄素（THC），其缺乏α，β-不饱和羰基部分并且颜色为白色。THC是否在分子水平上上级于姜黄素尚不清楚，因此是本文的重点。各种研究表明，姜黄素是一种比THC更有效的抗氧化剂;姜黄素（但不是THC）可以结合和抑制许多靶点，包括DNA（胞嘧啶-5）-甲基转移酶-1、血红素加氧酶-1、Nrf 2、β-连环蛋白、环氧合酶-2、NF-κ B、诱导型一氧化氮合酶、一氧化氮、淀粉样斑块、活性氧、血管内皮生长因子、细胞周期蛋白D1、谷胱甘肽、P300/CBP、5-脂氧合酶、胞浆磷脂酶A2、前列腺素E2、NF-κ B激酶-1、-2、P38 MAPK、p-Tau、肿瘤坏死因子-α、叉头框O3 a、CRAC的抑制剂;姜黄素可以抑制肿瘤细胞生长，并且比THC更有效地抑制病毒如甲型流感病毒和丙型肝炎病毒的细胞进入;姜黄素影响膜流动性;并且姜黄素在抑制佛波酯诱导的肿瘤促进方面也比THC更有效。然而，其他研究表明，THC在诱导GSH过氧化物酶、谷胱甘肽-S-转移酶、NADPH：醌还原酶和淬灭自由基方面优于姜黄素上级。大多数研究表明，THC具有较高的抗氧化活性，但姜黄素同时具有促氧化和抗氧化特性。
Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,β-unsaturated carbonyl moiety or to diketone groups present in curcumin. One of the major metabolites of curcumin is tetrahydrocurcumin (THC), which lacks α,β-unsaturated carbonyl moiety and is white in color. Whether THC is superior to curcumin on a molecular level is unclear and thus is the focus of this review. Various studies suggest that curcumin is a more potent antioxidant than THC; curcumin (but not THC) can bind and inhibit numerous targets including DNA (cytosine-5)-methyltransferase-1, heme oxygenase-1, Nrf2, β-catenin, cyclooxygenase-2, NF-kappaB, inducible nitric oxide synthase, nitric oxide, amyloid plaques, reactive oxygen species, vascular endothelial growth factor, cyclin D1, glutathione, P300/CBP, 5-lipoxygenase, cytosolic phospholipase A2, prostaglandin E2, inhibitor of NF-kappaB kinase-1, -2, P38MAPK, p-Tau, tumor necrosis factor-α, forkhead box O3a, CRAC; curcumin can inhibit tumor cell growth and suppress cellular entry of viruses such as influenza A virus and hepatitis C virus much more effectively than THC; curcumin affects membrane mobility; and curcumin is also more effective than THC in suppressing phorbol-ester-induced tumor promotion. Other studies, however, suggest that THC is superior to curcumin for induction of GSH peroxidase, glutathione-S-transferase, NADPH: quinone reductase, and quenching of free radicals. Most studies have indicated that THC exhibits higher antioxidant activity, but curcumin exhibits both pro-oxidant and antioxidant properties.
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