A Model of Progression to Help Identify Macular Damage Due to Glaucoma.
A Model of Progression to Help Identify Macular Damage Due to Glaucoma.
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DOI：
10.1167/iovs.64.15.8
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发表时间：
2023-12-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
中央斑包含围绕中央凹的神经节细胞层（GCL）的厚厚的甜甜圈形状区域。这个直径约为12度（3.5毫米）的区域对于驾驶、阅读和面部识别等日常功能至关重要。在这里，我们描述了一个模型的进展，昏迷损害这个GCL甜甜圈。该模型是基于文献支持的假设，它预测了GCL甜甜圈的昏迷性损伤模式，如光学相干断层扫描（OCT）所见。在描述了这个模型的假设和预测之后，我们根据实验室和文献中的数据对模型进行了测试。最后，说明了该模型的三种用途。第一，它提供了一种帮助，帮助临床医生专注于基本的中央黄斑，并提醒他们寻找其他，非青光眼的原因，当GCL损伤不符合模型预测的模式。其次，模型预测的进展模式为临床试验提供了替代终点。最后，该模型提供了一个启发，为今后的研究有关的解剖学基础的昏迷损害。
The central macula contains a thick donut shaped region of the ganglion cell layer (GCL) that surrounds the fovea. This region, which is about 12 degrees (3.5 mm) in diameter, is essential for everyday functions such as driving, reading, and face recognition. Here, we describe a model of progression of glaucomatous damage to this GCL donut. This model is based upon assumptions supported by the literature, and it predicts the patterns of glaucomatous damage to the GCL donut, as seen with optical coherence tomography (OCT). After describing the assumptions and predictions of this model, we test the model against data from our laboratory, as well as from the literature. Finally, three uses of the model are illustrated. One, it provides an aid to help clinicians focus on the essential central macula and to alert them to look for other, non-glaucomatous causes, when the GCL damage does not fit the pattern predicted by the model. Second, the patterns of progression predicted by the model suggest alternative end points for clinical trials. Finally, the model provides a heuristic for future research concerning the anatomic basis of glaucomatous damage.
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影响因子：
4.2
作者：
Nishida, Takashi;Moghimi, Sasan;Yamane, Maya L. M.;Wu, Jo-Hsuan;Mohammadzadeh, Vahid;Kamalipour, Alireza;Mahmoudinezhad, Golnoush;Liebmann, Jeffrey M.;Fazio, Massimo A.;Girkin, Christopher A.;Zangwill, Linda M.;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.
影响因子：
2.9
作者：
Hood, Donald C.;La Bruna, Sol;Tsamis, Emmanouil;Leshno, Ari;Melchior, Bruna;Grossman, Jennifer;Liebmann, Jeffrey M.;De Moraes, Carlos Gustavo
通讯作者：
De Moraes, Carlos Gustavo
DOI：
10.1097/wno.0000000000000422
发表时间：
2016-12
期刊：
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
影响因子：
--
作者：
Chen JJ;Kardon RH
通讯作者：
Kardon RH
影响因子：
4.4
作者：
Hood, Donald C.;Tsamis, Emmanouil;De Moraes, Carlos G.
通讯作者：
De Moraes, Carlos G.
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R