The Yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins.
The Yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins.
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DOI：
10.1016/j.chom.2008.06.004
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发表时间：
2008-07-17
影响因子：
30.3
通讯作者：
Lesser CF
中科院分区：
文献类型：
--
作者：
Siggers KA;Lesser CF
微生物病原体利用复杂的分泌系统将蛋白质递送到宿主细胞中。这些效应蛋白靶向并篡夺宿主细胞过程以促进感染并引起疾病。虽然分泌系统是保守的，但每种病原体都提供自己独特的效应子。这些效应蛋白的鉴定和表征一直是困难的，通常受到缺乏可检测的信号序列和功能冗余的限制。包括酵母、蠕虫、苍蝇和鱼在内的模型系统正在被用来规避这些问题。这篇技术综述详细介绍了酵母酿酒酵母作为鉴定和表征细菌效应子的系统的多功能性和实用性。
Microbial pathogens utilize complex secretion systems to deliver proteins into host cells. These effector proteins target and usurp host cell processes to promote infection and cause disease. While secretion systems are conserved, each pathogen delivers its own unique set of effectors. The identification and characterization of these effector proteins has been difficult, often limited by the lack of detectable signal sequences and functional redundancy. Model systems including yeast, worms, flies, and fish are being used to circumvent these issues. This technical review details the versatility and utility of yeast Saccharomyces cerevisiae as a system to identify and characterize bacterial effectors.
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影响因子：
4.5
作者：
Arnoldo A;Curak J;Kittanakom S;Chevelev I;Lee VT;Sahebol-Amri M;Koscik B;Ljuma L;Roy PJ;Bedalov A;Giaever G;Nislow C;Merrill AR;Lory S;Stagljar I
通讯作者：
Stagljar I
影响因子：
7.2
作者：
Jamir, Y;Guo, M;Alfano, JR
通讯作者：
Alfano, JR
影响因子：
3.1
作者：
Hardwidge, PR;Deng, WY;Finlay, BB
通讯作者：
Finlay, BB
影响因子：
4.4
作者：
Kristoffersen, P;Jensen, GB;Piskur, J
通讯作者：
Piskur, J
影响因子：
3.1
作者：
Derré, I;Isberg, RR
通讯作者：
Isberg, RR