Prognostic value of computed tomography characteristics for overall survival in patients with maxillary cancer.
Prognostic value of computed tomography characteristics for overall survival in patients with maxillary cancer.
复制标题
计算机断层扫描特征对上颌癌患者总生存期的预后价值。
DOI：
10.1186/s12885-016-2830-z
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发表时间：
2016-10-10
期刊：
影响因子：
3.8
通讯作者：
Tao X
中科院分区：
文献类型：
--
作者：
Yuan Y;Wang J;Wu Y;Li G;Tao X
我们的目的是确定术前计算机断层扫描（CT）的特点，最有效的预测总生存期（OS）的上颌癌（MC）患者。回顾性分析了2005年1月至2013年12月期间115例经组织病理学证实的原发性MC患者的CT图像，根据组织来源将其分为2种亚型（上皮和非上皮）。CT特征对OS的预后价值首先通过单变量Kaplan-Meier生存估计和对数秩检验来确定。用多变量考克斯比例风险模型进一步检验显著性预测因素。单因素生存分析中预测OS的CT特征为肿块的长径和短径、颈部最大淋巴结的长径和短径及邻近软组织浸润（P < 0.05）。在多因素考克斯分析中，显著独立的预测因素是肿块长径≥ 4.2 cm（风险比[HR] 1.8; 95%置信区间[CI] 1.1-3.0）和最大淋巴结的短径≥ 7 mm所有MC患者（HR 1.9; 95% CI 1.0-3.6）以及非上皮MC患者（分别为HR 3.1; 95% CI 1.2-8.0; HR 3.3; 95% CI 1.3-8.7）。术前肿瘤大小、淋巴结大小及邻近结构浸润的CT特征可预测MC患者的OS时间。本研究所提供的信息可用于临床实践，以了解可能的预后，并有利于临床决策。
Our aim was to identify the preoperative computed tomographic (CT) characteristics most efficient in predicting overall survival (OS) of patients with maxillary cancer (MC). A retrospective review of CT images was performed in 115 patients with histopathologically confirmed primary MC from January 2005 to December 2013, who were classified into 2 subtypes (epithelial and non-epithelial) according to tissue of origin. The prognostic value of CT characteristics for OS was determined firstly through univariate Kaplan-Meier survival estimates with log-rank tests. Significant predictors were further tested with multivariable Cox proportional hazard models. CT characteristics predictive of OS in univariate survival analysis were long and short diameter of the mass, long and short diameter of the largest cervical lymph node and adjacent soft tissue infiltration (P < 0.05). In the multivariable Cox analyses, the significantly independent predictors were long diameter of mass ≥ 4.2 cm (hazard ratio [HR] 1.8; 95 % confidence interval [CI] 1.1–3.0) and short diameter of the largest lymph node ≥ 7 mm (HR 1.9; 95 % CI 1.0–3.6) for all MC patients, as well as for non-epithelial MC patients (HR 3.1; 95 % CI 1.2–8.0; HR 3.3; 95 % CI 1.3–8.7, respectively). Preoperative CT characteristics of tumor size, lymph node size and adjacent structure infiltration are predictive of the OS time of MC patients. The information brought up in this study could be used in clinical practice to inform about the possible prognosis, and be beneficial to clinical decision making.
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影响因子：
8.4
作者：
Eisenhauer, E. A.;Therasse, P.;Verweij, J.
通讯作者：
Verweij, J.
CT 征象可以预测治疗反应和长期生存：一项针对局部晚期食管癌术前化疗的研究
影响因子：
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作者：
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DOI：
10.1186/1470-7330-14-15
发表时间：
2014-04-28
期刊：
Cancer imaging : the official publication of the International Cancer Imaging Society
影响因子：
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作者：
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通讯作者：
Gődény M
影响因子：
5.1
作者：
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通讯作者：
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影响因子：
19.7
作者：
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通讯作者：
Polansky, M