Prognostic factors in advanced pharyngeal and oral cavity cancer; significance of multimodality imaging in terms of 7th edition of TNM.
Prognostic factors in advanced pharyngeal and oral cavity cancer; significance of multimodality imaging in terms of 7th edition of TNM.
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DOI：
10.1186/1470-7330-14-15
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发表时间：
2014-04-28
期刊：
影响因子：
--
通讯作者：
Gődény M
中科院分区：
文献类型：
--
作者：
Gődény M
与大多数癌症一样，咽喉癌和口腔癌的预后很大程度上取决于肿瘤分期。体格检查，包括内窥镜检查，应结合技术放射成像记录肿瘤的精确范围。头颈部TNM分期系统实际上是一种解剖学分期系统，它描述了原发肿瘤的解剖范围以及区域淋巴结和远处转移的累及情况。TNM分期系统的修改不仅应考虑专家意见和已发表的文献报告，还应考虑改进肿瘤范围评估的技术进步和治疗策略的转变范例。肿瘤的“T”期是由它的大小、侵袭的深度和对重要结构的影响来定义的。在第7版TNM分类中，对于T4期肿瘤（大于4cm），引入了a和b亚类来表示重要结构的累及及其是否适合手术切除（鼻咽癌除外）。淋巴结转移是头颈部鳞状细胞癌预后最重要的预测因子。因此，更好、更可靠的肿瘤前处理评估方法对于确保肿瘤的临床评估接近其实际病理程度至关重要。CT和MRI对评估晚期咽喉癌和口腔癌的扩散都很有用。MRI在大多数原发肿瘤部位的显像上是优越的。
As with most cancers the prognosis in pharyngeal and oral cavity cancer largely depends on tumour stage. Physical examination, including endoscopy should be combined with technical radiologic imaging to record the precise extent of tumour. The TNM staging system of the head and neck region is, in fact, an anatomic staging system that describes the anatomic extent of the primary tumour as well as the involvement of regional lymph nodes and distant metastases. Modifications in the TNM staging system should consider not only the expert opinions and published reports in the literature but the technical advances in technology for improved assessment of tumour extent and the shifting paradigms in therapeutic strategies. “T” stage of the tumour is defined by its size, the depth of the invasion and the involvement of vital structures. In the 7th edition of TNM classification, for stage T4 tumors (larger than 4 cm), subcategories a and b were introduced to indicate the involvement of vital structures and their suitability for surgical resection (except for nasopharynx cancer). Nodal metastasis is the most important predictor of outcome for squamous cell cancer of the head and neck. Better and more reliable methods of pretreatment tumour assessment are therefore crucial to ensure that the clinical assessment of tumor approximates its actual pathologic extent. CT and MRI are both useful for assessing extensions of pharyngeal- and oral cavity cancer in advanced stage. MRI is superior in visualizing most primary tumour sites.
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影响因子：
3.3
作者：
Chong, V. F. H.;Ong, C. K.
通讯作者：
Ong, C. K.
DOI：
10.1102/1470-7330.2005.0029
发表时间：
2005-11-23
期刊：
Cancer imaging : the official publication of the International Cancer Imaging Society
影响因子：
--
作者：
Chong, Vincent
通讯作者：
Chong, Vincent
DOI：
10.1002/hed.20173
发表时间：
2005-04-01
影响因子：
2.9
作者：
Nason, RW;Torchia, MG;Thliveris, J
通讯作者：
Thliveris, J
DOI：
10.1002/hed.10355
发表时间：
2004-01-01
影响因子：
2.9
作者：
Kontio, R;Leivo, I;Atula, T
通讯作者：
Atula, T
DOI：
10.1002/hed.20261
发表时间：
2005-11-01
影响因子：
2.9
作者：
Loh, KS;Brown, DH;Irish, JC
通讯作者：
Irish, JC