Exhaled carbon monoxide in asthmatics: a meta-analysis.
Exhaled carbon monoxide in asthmatics: a meta-analysis.
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哮喘患者呼出的一氧化碳：荟萃分析
DOI：
10.1186/1465-9921-11-50
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发表时间：
2010-04-30
影响因子：
5.8
通讯作者：
Barnes PJ
中科院分区：
文献类型：
--
作者：
Zhang J;Yao X;Yu R;Bai J;Sun Y;Huang M;Adcock IM;Barnes PJ
背景：气道炎症的非侵入性评估在哮喘治疗中具有潜在的优势。呼出一氧化碳（eCO）的测量是廉价的，并已提出反映气道炎症和氧化应激，但目前的数据是相互矛盾的。本荟萃分析的目的是确定eCO是否在哮喘患者中升高，是否受类固醇治疗的调节，是否反映疾病的严重程度和控制。方法采用Medline、Embase和Cochrane数据库系统检索1997 ~ 2009年发表的英文文献。观察性研究比较了非吸烟哮喘患者和健康受试者或哮喘患者在类固醇治疗前后的eCO。数据由两位研究者独立提取，并根据异质性的程度，使用固定效应或随机效应荟萃分析得出加权平均差异。结果18项研究被纳入meta分析。哮喘患者的eCO水平明显高于健康受试者，间歇性哮喘患者的eCO水平明显高于持续性哮喘患者。然而，在横断面研究中，eCO不能区分类固醇治疗的哮喘患者和未使用类固醇的患者，也不能区分控制哮喘和部分控制哮喘与未控制哮喘。相比之下，皮质类固醇治疗一个疗程后，eCO显著降低。结论哮喘患者seco水平升高，但仅部分反映病情严重程度和病情控制情况。eCO可能是非吸烟哮喘患者气道炎症和氧化应激的潜在有用的非侵入性生物标志物。
BackgroundThe non-invasive assessment of airway inflammation is potentially advantageous in asthma management. Exhaled carbon monoxide (eCO) measurement is cheap and has been proposed to reflect airway inflammation and oxidative stress but current data are conflicting. The purpose of this meta-analysis is to determine whether eCO is elevated in asthmatics, is regulated by steroid treatment and reflects disease severity and control.MethodsA systematic search for English language articles published between 1997 and 2009 was performed using Medline, Embase and Cochrane databases. Observational studies comparing eCO in non-smoking asthmatics and healthy subjects or asthmatics before and after steroid treatment were included. Data were independently extracted by two investigators and analyzed to generate weighted mean differences using either a fixed or random effects meta-analysis depending upon the degree of heterogeneity.Results18 studies were included in the meta-analysis. The eCO level was significantly higher in asthmatics as compared to healthy subjects and in intermittent asthma as compared to persistent asthma. However, eCO could not distinguish between steroid-treated asthmatics and steroid-free patients nor separate controlled and partly-controlled asthma from uncontrolled asthma in cross-sectional studies. In contrast, eCO was significantly reduced following a course of corticosteroid treatment.ConclusionseCO is elevated in asthmatics but levels only partially reflect disease severity and control. eCO might be a potentially useful non-invasive biomarker of airway inflammation and oxidative stress in nonsmoking asthmatics.
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影响因子：
9.6
作者：
Sato, S;Nishimura, K;Mishima, M
通讯作者：
Mishima, M
影响因子：
3.7
作者：
Antczak, A;Kharitonov, SA;Barnes, PJ
通讯作者：
Barnes, PJ
影响因子：
1.9
作者：
Grover, Ravneet Singh;Kumar, Raj
通讯作者：
Kumar, Raj
DOI：
10.1164/ajrccm.153.1.8542158
发表时间：
1996-01-01
影响因子：
24.7
作者：
Kharitonov, SA;Yates, DH;Barnes, PJ
通讯作者：
Barnes, PJ
影响因子：
9.6
作者：
Middleton, ET;Morice, AH
通讯作者：
Morice, AH