Changes in Peptidergic Innervation in Chronic Pancreatitis
Changes in Peptidergic Innervation in Chronic Pancreatitis
复制标题
慢性胰腺炎肽能神经支配的变化
作者：
M. Büchler;E. Weihe;H. Friess;P. Malfertheiner;E. Bockman;S. Müller;D. Nohr;H. Beger
我们试图确定慢性胰腺炎患者的肽能神经支配改变的特征。从慢性胰腺炎患者的胰腺组织进行了分析，免疫组化使用抗神经肽Y，酪氨酸羟化酶，血管活性肠多肽，肽组氨酸异亮氨酸，降钙素基因相关肽，P物质，分别。根据最近的研究结果，发现与来自器官供体的对照胰腺相比，小叶内和小叶间神经束的数量和直径增加。慢性胰腺炎时肽能神经支配模式的显著变化与这些改变的神经有关。它包括降钙素基因相关肽和P物质在这些神经中包含的许多纤维的免疫染色的增强。相邻切片显示免疫反应性P物质和免疫反应性降钙素基因相关肽在这些纤维中共存。由于这两种肽通常被认为是疼痛递质的候选者，我们的研究结果提供了进一步的证据表明，胰腺神经本身的变化可能是慢性胰腺炎持久疼痛综合征的原因。
We sought to identify characteristics of peptidergic innervation that altered in patients with chronic pancreatitis. Pancreatic tissue removed from patients with chronic pancreatitis was analyzed by immunohistochemistry using antisera against neuropeptide Y, tyrosine hydroxylase, vasoactive intestinal polypeptide, peptide histidine isoleucine, calcitonin gene-related peptide, and substance P, respectively. In accordance with recent findings, the number and diameter of intralobular and interlobular nerve bundles were found to be increased as compared with control pancreas from organ donors. The striking change in the peptidergic innervation pattern in chronic pancreatitis concerned these altered nerves. It consisted of an intensification of the immunostaining for calcitonin gene-related peptide and substance P in numerous fibers contained in these nerves. Adjacent sections showed that immunoreactive substance P and immunoreactive calcitonin gene-related peptide coexisted in these fibers. Because both of these peptides are generally regarded as pain transmitter candidates, our findings provide further evidence that changes in pancreatic nerves themselves might be responsible for the long-lasting pain syndrome in chronic pancreatitis.
登录
查看更多内容
正常大鼠和辣椒素治疗大鼠消化系统中降钙素基因相关肽免疫反应性的分布和特征。
影响因子：
29.4
作者：
Sternini,C;ReeveJr,JR;Brecha,N
通讯作者：
Brecha,N
缓激肽作为疼痛介质：受体定位于感觉神经元，拮抗剂具有镇痛作用。
DOI：
10.1073/pnas.85.9.3245
发表时间：
1988
影响因子：
11.1
作者：
Steranka,LR;Manning,DC;DeHaas,CJ;Ferkany,JW;Borosky,SA;Connor,JR;Vavrek,RJ;Stewart,JM;Snyder,SH
通讯作者：
Snyder,SH
DOI：
10.1073/pnas.84.3.881
发表时间：
1987-02-01
影响因子：
11.1
作者：
KRAUSE, JE;CHIRGWIN, JM;HERSHEY, AD
通讯作者：
HERSHEY, AD
影响因子：
21.1
作者：
S. H. Buck;T. Burks
通讯作者：
S. H. Buck;T. Burks
感觉神经肽调节淋巴细胞功能。
DOI：
--
发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Payan,DG;Goetzl,EJ
通讯作者：
Goetzl,EJ