Enhanced methods for visualizing myocardial perfusion with peripheral venous injection of Levovist®: Application of triggered harmonic imaging and triggered harmonic power Doppler imaging techniques
Enhanced methods for visualizing myocardial perfusion with peripheral venous injection of Levovist®: Application of triggered harmonic imaging and triggered harmonic power Doppler imaging techniques
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通过外周静脉注射 Levovist® 实现心肌灌注可视化的增强方法：触发谐波成像和触发谐波功率多普勒成像技术的应用
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
M. Yamagishi
中科院分区：
文献类型：
--
作者：
K. Hirooka;K. Miyatake;A. Hanatani;K. Komamura;S. Nakatani;Y. Yasumura;M. Yamagishi
目的：本研究的目的是确定触发谐波成像（THI）或触发谐波能量多普勒成像（THPDI）是否可以通过外周静脉注射第一代超声心动图造影剂Levovist®获得心肌造影增强。方法：在体模模型中，我们研究了声功率、谐波滤波器、发射频率和换能器焦点位置对Levovist®的影响。然后，在8只闭胸犬中使用Levovist®推注进行基波、谐波或谐波功率多普勒成像和ECG触发成像。结果：在体模模型中，最高透射功率（机械指数1.6）、中谐波滤波器和焦点位置（6cm）均能获得最佳的THI和THPDI增强对比度。谐波能量多普勒脉冲重复频率越高（5500 Hz），强化越明显。在动物模型中，触发基波成像不能观察到明显的心肌对比，心肌各感兴趣区（ROI）的强度无明显变化。然而，使用THI可以获得均匀的心肌对比度，THI的条件是最高的发射功率、与体模模型相同的中谐波滤波器、较低的发射频率（1.8 MHz）和位于左心室中部的焦点位置。各感兴趣区的峰值强度在灰度级上显著增加。此外，THPDI在视觉上引起心肌对比增强。结论：这些结果表明，使用外周静脉注射Levovist®，THI和THPDI产生明显的MCE。
Objectives:The purpose of this study was to determine whether triggered harmonic imaging (THI) or triggered harmonic power Doppler imaging (THPDI) could obtain the myocardial contrast enhancement using peripheral venous injection of a first generation echocardiographic contrast agent, Levovist®. Methods:In a phantom model, we examined the influence of an acoustic power, harmonic filters, transmitted frequencies and focus positions of transducer on Levovist®. Then fundamental, harmonic or harmonic power Doppler imaging were performed with ECG-triggered imaging in eight closed-chest dogs using bolus injection of Levovist®. Results:In a phantom model, the highest transmission power (Mechanical index 1.6), a medium harmonic filter and a focus position (6 cm) resulted in the best enhanced contrast in both THI and THPDI. Furthermore, higher pulse repetition frequency (5500 Hz) of harmonic power Doppler made clearer enhancement. In animal models, we could not observe the apparent myocardial contrast using triggered fundamental imaging, and the intensity of each region of interest (ROI) of myocardium had not changed significantly. However, homogeneous myocardial contrast could be obtained using THI, which was conditioned on the highest transmission power, a medium harmonic filter same as the phantom model, at a lower transmitted frequency (1.8 MHz) and a focus position, which were located in the middle portion of the left ventricle. The peak intensity of each ROI increased significantly in a gray level. Furthermore, THPDI caused emphasized myocardial contrast visually. Conclusions:These results indicate that THI and THPDI produce obvious MCE using peripheral venous injection of Levovist®.
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