Assessment of regional myocardial perfusion with myocardial contrast echocardiography in a canine model of varying degrees of coronary stenosis.
Assessment of regional myocardial perfusion with myocardial contrast echocardiography in a canine model of varying degrees of coronary stenosis.
复制标题
在不同程度冠状动脉狭窄的犬模型中用心肌造影超声心动图评估局部心肌灌注。
DOI：
10.1016/0002-8703(94)90509-6
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发表时间：
1994
影响因子：
4.8
通讯作者：
Quiñones,MA
中科院分区：
文献类型：
--
作者：
Desir,RM;Cheirif,J;Bolli,R;Zoghbi,WA;Hoyt,BD;Quiñones,MA
先前的研究表明，心肌超声造影可用于检测犬急性冠状动脉狭窄模型的相对区域灌注不足。本研究的目的是确定用无菌超声人血清白蛋白制剂（Albunex, Molecular Biosystems, San Diego, california）进行心肌造影超声心动图是否可以检测不同严重程度的冠状动脉狭窄的存在。将结果与16只开胸犬在基线期间（不同严重程度的冠状动脉狭窄形成后和双嘧达莫引起充血高峰时）用放射性标记微球评估的心肌血流进行比较。当检测血流比（即对照区/缺血区血流）时，发现时间-强度曲线下面积与放射性微球血流具有良好的相关性（r= 0.94,p< 0.0001），可以区分轻度和重度狭窄。然而，对照区心肌造影回声一致低估了双嘧达莫引起的充血。这可以部分解释为双嘧达莫同时增加冠状动脉血流量和血容量，以及高流量时微泡浓度高导致超声信号衰减。心肌超声造影可以量化不同程度冠状动脉狭窄时受损心肌的数量。
Previous studies showed that myocardial contrast echocardiography can be used to detect relative regional underperfusion in a canine model of critical coronary stenoses. The aim of this study was to determine if myocardial contrast echocardiography performed with a sterile sonicated human serum albumin preparation (Albunex, Molecular Biosystems, San Diego, Calif.) could detect the presence of coronary stenoses of variable degrees of severity. The results were compared with myocardial blood flow as assessed by radiolabeled microspheres in 16 open-chest dogs during baseline, following the creation of a coronary stenosis of variable severity and at the peak of dipyridamole-induced hyperemia. When flow ratios (that is, flow in the control area/ischemic area) were examined, a good correlation was observed between the area under the time-intensity curve and radioactive microsphere blood flow (r= 0.94,p< 0.0001), which allowed distinction of mild from severe stenosis. However, a consistent underestimation of the dipyridamole-induced hyperemia by myocardial contrast echo was seen in the control zone. This could be partially explained by a simultaneous increase in coronary blood flow and blood volume with dipyridamole and by attentuation of the ultrasound signal because of the high concentration of microbubbles at high flows. Myocardial contrast echocardiography can quantitate the amount of jeopardized myocardium during various degrees of coronary stenoses.
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影响因子：
9.6
作者：
M. Klicpera;D. Glogar;H. Mayr;W. Mohl;U. Losert;F. Kaindl
通讯作者：
F. Kaindl
对比回波强度对人体冠状循环和体外流速增加的反应之间的不一致。
影响因子：
4.8
作者：
D. Rovai;M. Lombardi;G. Ghelardini;M. Marzilli;L. Taddei;C. Michelassi;A. Distante;A. DeMaria;A. L'Abbate
通讯作者：
A. L'Abbate
急性冠状动脉闭塞后局部心肌血流的对比超声心动图评估。
影响因子：
37.8
作者：
A. Kemper;T. Force;R. Kloner;M. Gilfoil;L. Perkins;S. Hale;K. Alker;A. Parisi
通讯作者：
A. Parisi
使用对比增强超声心动图评估心肌梗塞的位置和大小。
影响因子：
24
作者：
William F. Armstrong;S. West;Thomas M. Mueller;James C. Dillon;Harvey Feigenbaum
通讯作者：
Harvey Feigenbaum
回声对比效应的定量。
DOI：
--
发表时间：
1986
期刊：
American journal of physiologic imaging
影响因子：
--
作者：
S. Powsner;M. Keller;J. Saniie;S. Feinstein
通讯作者：
S. Feinstein