Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines
Lymphoid neogenesis: de novo formation of lymphoid tissue in chronic inflammation through expression of homing chemokines
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淋巴新生：慢性炎症中淋巴组织通过归巢趋化因子的表达从头形成
DOI：
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发表时间：
2001
影响因子：
5.5
通讯作者：
P. Hjelmström
中科院分区：
文献类型：
--
作者：
P. Hjelmström
Chronic inflammation is a complex pathophysiological process with accumulation of mononuclear cells seen in response to invading pathogens, neoplastic transformation, or autoimmune recognition of self‐antigens. The inflammatory process has evolved to facilitate effective elimination of pathogens and tumors and it is normally transient and turned off when the causative stimulus has been eliminated. Occasionally, however, the process is sustained for a long time and can lead to severe tissue damage. This is seen in organ‐specific autoimmune diseases such as rheumatoid arthritis, Sjögren’s syndrome, and Hashimoto’s thyroiditis, but also in infectious diseases such as Helicobacter pylori‐induced gastritis. Disturbingly, many of these chronic inflammatory diseases are associated with an increased risk for neoplastic transformation and development of lymphomas. This review summarizes experimental evidence suggesting that chronic inflammation involves ectopic de novo formation of organized lymphoid tissue and that this lymphoid neogenesis is regulated by expression of homing chemokines.
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影响因子：
--
作者：
Carol L. Young;T. C. Adamson;J. Vaughan;Robert I. Fox
通讯作者：
Carol L. Young;T. C. Adamson;J. Vaughan;Robert I. Fox
影响因子：
6
作者：
Hjelmström, P;Fjell, J;Ruddle, NH
通讯作者：
Ruddle, NH
影响因子：
4.4
作者：
James J. Campbell;Junliang Pan;E. Butcher
通讯作者：
James J. Campbell;Junliang Pan;E. Butcher
影响因子：
--
作者：
STEERE, AC;DURAY, PH;BUTCHER, EC
通讯作者：
BUTCHER, EC
DOI：
--
发表时间：
1997-11
期刊：
The American journal of pathology
影响因子：
--
作者：
P. Klimiuk;J. Goronzy;J. Björnsson;R. Beckenbaugh;C. Weyand
通讯作者：
P. Klimiuk;J. Goronzy;J. Björnsson;R. Beckenbaugh;C. Weyand