Adipose tissue insulin resistance in adolescents with and without type 2 diabetes.
Adipose tissue insulin resistance in adolescents with and without type 2 diabetes.
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DOI：
10.1111/j.2047-6310.2013.00189.x
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发表时间：
2014-10
影响因子：
3.8
通讯作者：
Nadeau KJ
中科院分区：
文献类型：
--
作者：
Kelsey MM;Forster JE;Van Pelt RE;Reusch JE;Nadeau KJ
The incidence of type 2 diabetes mellitus (T2D) is increasing in youth, yet little is known about the underlying pathophysiology. Decreased insulin suppression of lipolysis and elevated non-esterified free fatty acid (NEFA) concentrations are known to be associated with insulin resistance and T2D in adults, but less is known about the relationship in adolescents. To assess adipose tissue IR (insulin suppression of lipolysis) and its metabolic correlates in lean, obese and T2D adolescents. 47 lean, obese and T2D youth underwent hyperinsulinemic (80mU*m−2*min−1), euglycemic clamps. NEFAs were measured at baseline and during steady state. Insulin-mediated suppression of lipolysis (%NEFA suppression from baseline) was calculated and metabolic risk factors were assessed by %NEFA suppression tertile. There was expected variability in %NEFA suppression within obese and T2D youth, but a subset had significantly reduced suppression of lipolysis. NEFA suppression tertile was significantly inversely associated with fasting triglycerides (p=0.0001), log alanine aminotransferase (ALT, p=0.02), and low-density lipoprotein cholesterol (p=0.0002). Marked adipose tissue IR occurs in some obese and T2D adolescents, which may result in release of triglycerides into the circulation and liver deposition of fatty acids, as evidenced by higher ALT in poor NEFA suppressors.
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
DOI：
10.1152/ajpendo.2001.280.6.e1000
发表时间：
2001-06-01
影响因子：
5.1
作者：
Basu, A;Basu, R;Jensen, MD
通讯作者：
Jensen, MD
DOI：
10.1161/01.atv.12.8.911
发表时间：
1992-08-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
MENSINK, RP;KATAN, MB
通讯作者：
KATAN, MB
影响因子：
5.8
作者：
Nadeau, Kristen J.;Zeitler, Phillip S.;Regensteiner, Judith G.
通讯作者：
Regensteiner, Judith G.
影响因子：
3.8
作者：
Kim JS;Lê KA;Mahurkar S;Davis JN;Goran MI
通讯作者：
Goran MI