The impact of bisphenol A on the placenta†.
The impact of bisphenol A on the placenta†.
复制标题
双酚A对胎盘的影响†。
DOI：
10.1093/biolre/ioac001
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发表时间：
2022-05-17
影响因子：
3.6
通讯作者：
Tuteja, Geetu
中科院分区：
文献类型：
--
作者：
Adu-Gyamfi, Enoch Appiah;Rosenfeld, Cheryl S.;Tuteja, Geetu
双酚A （BPA）是一种干扰内分泌的化学物质，被用于生产各种各样的塑料和普通家居用品。因此，有可能持续接触这种化合物。BPA暴露与某些胎盘相关的产科并发症有关，如先兆子痫、胎儿生长受限、流产和早产。然而，BPA暴露如何导致这些疾病仍不确定。因此，我们在此总结了双酚a对胎盘形态和代谢状态的影响，并提出了双酚a影响胎盘的机制，可能导致产科并发症。目前的研究结果表明，BPA会引起胎盘的病理变化，并扰乱其代谢活动。BPA暴露浓度不同，可引起滋养细胞的凋亡或抗凋亡信号，并可在促进滋养细胞融合的同时抑制滋养细胞的迁移和侵袭，影响妊娠。因此，应尽量减少孕妇使用双酚a产品，并尽可能探索和使用危害较小的替代化学品。双酚A是一种干扰内分泌的化学物质，常见于家庭用品中的塑料中，它会影响胎盘发育，可能导致妊娠并发症。
Bisphenol A (BPA), an endocrine-disrupting chemical, is used to produce a wide variety of plastic and common house-hold items. Therefore, there is potential continual exposure to this compound. BPA exposure has been linked to certain placenta-associated obstetric complications such as preeclampsia, fetal growth restriction, miscarriage, and preterm birth. However, how BPA exposure results in these disorders remains uncertain. Hence, we have herein summarized the reported impacts of BPA on the morphology and metabolic state of the placenta and have proposed mechanisms by which BPA affects placentation, potentially leading to obstetric complications. Current findings suggest that BPA induces pathological changes in the placenta and disrupts its metabolic activities. Based on exposure concentrations, BPA can elicit apoptotic or anti-apoptotic signals in the trophoblasts, and can exaggerate trophoblast fusion while inhibiting trophoblast migration and invasion to affect pregnancy. Accordingly, the usage of BPA products by pregnant women should be minimized and less harmful alternative chemicals should be explored and employed where possible. This review provides insight into the mechanisms by which bisphenol A, an endocrine-disrupting chemical that is used in plastic found in common household items, affects placental development, potentially leading to pregnancy complications.
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