Dissociation of morphological and physiological changes associated with long-term memory in aplysia.

Dissociation of morphological and physiological changes associated with long-term memory in aplysia.
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海兔长期记忆相关的形态和生理变化的分离。

DOI:
10.1152/jn.00335.2004
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发表时间:
2004
期刊:
Journal of neurophysiology.
影响因子:
--
通讯作者:
Cleary,LeonardJ
Cleary,LeonardJ
中科院分区:
--
文献类型:
--
作者:
Wainwright,MarcyL;Byrne,JohnH;Cleary,LeonardJ

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神经突生长通常被认为是通过形成新的突触接触来促进长期学习的过程。长期的致敏训练对行为的影响仅限于动物接受训练的一侧,感觉运动突触的强度也发生了变化。相反,训练在动物的两侧产生静脉曲张形成。然而,与跟随神经元的同位体仅在训练侧得到增强。结构和功能相关性的分离表明,关键的调控步骤是下游的产物,可能在新的过程和激活新的突触的目标。
Neurite outgrowth is a process commonly thought to contribute to long-term learning by formation of new synaptic contacts. The behavioral effects of long-term sensitization training inAplysiawere restricted to the trained side of the animal as were changes in strength of the sensorimotor synapse. In contrast, training produced varicosity formation on both sides of the animal. Appositions with follower neurons, however, were enhanced only on the trained side. The dissociation of structural and functional correlates suggests that key regulatory steps are downstream from outgrowth, possibly in the targeting of new processes and activation of new synapses.
血清素对培养的海兔感觉神经元的兴奋性产生长期变化,这取决于新的蛋白质合成
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