Engineered antigen-specific regulatory T cells for autoimmune skin conditions.
Engineered antigen-specific regulatory T cells for autoimmune skin conditions.
复制标题
针对自身免疫性皮肤疾病设计的抗原特异性调节性T细胞。
DOI：
10.1016/j.autrev.2021.102761
复制
发表时间：
2021-03
影响因子：
13.6
通讯作者：
Poole, I. Caroline Le
中科院分区：
文献类型：
--
作者：
Mukhatayev, Zhussipbek;Ostapchuk, Yekaterina O.;Fang, Deyu;Poole, I. Caroline Le
关键词：
调节性T细胞（Tregs）是负责调节免疫反应的T细胞的一个子集，从而维持免疫稳态并为自身和非自身抗原提供免疫耐受性。越来越多的研究揭示了多种自身免疫性疾病的Treg数量和功能。 Treg缺乏会导致多种自身免疫性皮肤疾病的发展，包括白癜风，脱发，pemphigoid和Pemphigus，牛皮癣和全身性硬化症。使用多克隆Treg进行了许多临床试验，用于自身免疫条件，但是使用使用T细胞受体（TCR）或嵌合抗原受体（CAR）构建体设计的抗原特异性Treg可以显着提高效率。在这篇综述中，我们系统地审查了自身免疫性皮肤条件下Tregs的频率，功能受损和表型特征。我们还概述了在动物模型和诊所中测试的TCR和基于汽车的抗原特异性Treg的新进展。仔细讨论了每种方法的优点和局限性，强调了与自身免疫性皮肤疾病患者的可能临床相关性。此外，我们已经审查了工程抗原特异性Treg的潜在方法，以及克服临床应用中可能障碍的策略。因此，可以使用自体性收益细胞转移来注入抗原特异性Treg，以恢复Treg数量并为自身免疫性皮肤疾病提供局部免疫耐受性。
Regulatory T cells (Tregs) are a subset of T cells responsible for the regulation of immune responses, thereby maintaining immune homeostasis and providing immune tolerance to both self and non-self-antigens. An increasing number of studies revealed Treg numbers and functions in a variety of autoimmune diseases. Treg deficiency can cause the development of several autoimmune skin diseases including vitiligo, alopecia areata, pemphigoid and pemphigus, psoriasis, and systemic sclerosis. Many clinical trials have been performed for autoimmune conditions using polyclonal Tregs, but efficiency can be significantly improved using antigen-specific Tregs engineered using T cell receptor (TCR) or chimeric antigen receptor (CAR) constructs. In this review, we systematically reviewed altered frequencies, impaired functions, and phenotypic features of Tregs in autoimmune skin conditions. We also summarized new advances in TCR and CAR based antigen-specific Tregs tested both in animal models and in clinics. The advantages and limitations of each approach were carefully discussed emphasizing possible clinical relevance to patients with autoimmune skin diseases. Moreover, we have reviewed potential approaches for engineering antigen-specific Tregs, and strategies for overcoming possible hurdles in clinical applications. Thereby, antigen-specific Tregs can be infused using autologous adoptive cell transfer to restore Treg numbers and to provide local immune tolerance for autoimmune skin disorders.
登录
查看更多内容
影响因子：
--
作者：
Chihara N;Madi A;Karwacz K;Awasthi A;Kuchroo VK
通讯作者：
Kuchroo VK
影响因子：
24.5
作者：
Canavan JB;Scottà C;Vossenkämper A;Goldberg R;Elder MJ;Shoval I;Marks E;Stolarczyk E;Lo JW;Powell N;Fazekasova H;Irving PM;Sanderson JD;Howard JK;Yagel S;Afzali B;MacDonald TT;Hernandez-Fuentes MP;Shpigel NY;Lombardi G;Lord GM
通讯作者：
Lord GM
影响因子：
7.5
作者：
Arruda, Lucas C. M.;Malmegrim, Kelen C. R.;Oliveira, Maria Carolina
通讯作者：
Oliveira, Maria Carolina
影响因子：
3.5
作者：
Banica, Leontina;Besliu, Alina;Matache, Cristiana
通讯作者：
Matache, Cristiana
影响因子：
4.8
作者：
Baraut, J.;Grigore, E. L.;Michel, L.
通讯作者：
Michel, L.