Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells.
Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells.
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DOI：
10.1021/mp900316a
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发表时间：
2010-06-07
影响因子：
4.9
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Hu CM;Kaushal S;Tran Cao HS;Aryal S;Sartor M;Esener S;Bouvet M;Zhang L
目前针对胰腺癌的化疗方案几乎没有成功，因为肿瘤血管化不良严重限制了肿瘤药物的递送。高剂量靶向给药，通过给药载体在肿瘤定位时释放大量有效载荷，因此是对抗这种致命疾病的一种有希望的替代策略。在此，我们合成了抗cea半抗体缀合的脂质聚合物杂化纳米颗粒，并对其配体缀合率、物理化学性质和靶向胰腺癌细胞的能力进行了表征。在相同的药物负荷下，半抗体靶向纳米颗粒比相应的非靶向纳米颗粒具有更强的抗癌效果。
Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a drug delivery vehicle releases a large payload upon tumor localization, is thus a promising alternative strategy against this lethal disease. Herein, we synthesize anti-CEA half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding non-targeted nanoparticles.
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