Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions.
Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions.
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DOI：
10.3389/fnins.2022.757091
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发表时间：
2022
影响因子：
4.3
通讯作者：
Smirnakis SM
中科院分区：
文献类型：
--
作者：
Keliris GA;Shao Y;Schmid MC;Augath M;Logothetis NK;Smirnakis SM
在成人视觉系统中，视网膜损伤后初级视觉皮质(V1)的地形图重组已被广泛研究。相比之下，视网膜损伤后高阶纹外区的可塑性研究较少。在这里，我们使用功能磁共振成像来研究在诱导4只成年猕猴永久性的、双眼的、同名的视网膜损伤后视觉区域V2/V3的重组。我们发现，在V2/V3病变投影区(LPZ)中，绝大多数在病变当天没有显示视觉调制的体素在2周后显示出显著的视觉调制，并且在我们的观察持续时间(4-5个月)之后，平均调制强度保持大致稳定。V2/V3 LPZ内视觉调制体素的偏心率分布比损伤前跨越了更大的范围，这表明LPZ内的神经元通过接受来自LPZ中心凹或LPZ外围边缘的输入进行重组，具体取决于距离。总体而言，我们得出结论，成年猕猴的V2/V3区在视网膜病变明显超过V1区的相应容量后，显示出显著的地形重组能力。
In the adult visual system, topographic reorganization of the primary visual cortex (V1) after retinal lesions has been extensively investigated. In contrast, the plasticity of higher order extrastriate areas following retinal lesions is less well studied. Here, we used fMRI to study reorganization of visual areas V2/V3 following the induction of permanent, binocular, homonymous retinal lesions in 4 adult macaque monkeys. We found that the great majority of voxels that did not show visual modulation on the day of the lesion in the V2/V3 lesion projection zone (LPZ) demonstrated significant visual modulations 2 weeks later, and the mean modulation strength remained approximately stable thereafter for the duration of our observations (4–5 months). The distribution of eccentricities of visually modulated voxels inside the V2/V3 LPZ spanned a wider range post-lesion than pre-lesion, suggesting that neurons inside the LPZ reorganize by receiving input either from the foveal or the peripheral border of the LPZ, depending on proximity. Overall, we conclude that area V2/V3 of adult rhesus macaques displays a significant capacity for topographic reorganization following retinal lesions markedly exceeding the corresponding capacity of area V1.
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影响因子：
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作者：
DEWEERD, P;GATTASS, R;UNGERLEIDER, LG
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